Transcriptional Control of Apical-Basal Polarity Regulators
Abstract
:1. Introduction
2. Polarity Gene Expression during Epithelial to Mesenchymal Transition
3. Polarity Gene Expression and the Regulation of Asymmetric Stem Cell Division
4. Polarity Gene Expression in Other Processes
5. Discussion
6. Conclusions and Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Human | D. melanogaster | C. elegans | Upstream Transcription Factors |
---|---|---|---|
Par complex | |||
PARD3 | baz | par-3 | Snail (Drosophila, gastrulation) PHA-4 (C. elegans, epithelium) |
PARD6A | par-6 | par-6 | |
PKCλ, PKCζ | aPKC | pkc-3 | Zif (Drosophila, neuroblast) Myc-Tip60 (Drosophila, neuroblast) ci (Drosophila, wing) |
CDC42 | cdc42 | cdc-42 | Tinman/Nkx2-5 (Drosophila/mouse, heart development) |
Scrib complex | |||
SCRIB * | scrib | let-413 | Salm and Salr (Drosophila, wing) |
DLG1, DLG2, DLG3, DLG4 | dlg1 | dlg-1 | Snail (human, tumorigenesis) PHA-4 (C. elegans, epithelium) Salm and Salr (Drosophila, wing) |
LLGL1, LLGL2 | l(2)gl | lgl-1 | Snail (human, breast cancer) ZEB-1 (human, breast cancer) |
Crumbs complex | |||
CRB1, CRB2, CRB3 | crb | crb-1, crb-3 | Snail (MDCK) ZEB-1 (human, breast cancer) MUC1-C (human, breast cancer) ERα (human, breast cancer) hGATA6/Srp (human/Drosophila, EMT) Stat92E (Drosophila, spiracle) |
PALS1 | sdt | magu-2 | Snail (MDCK) Srp (Drosophila, EMT) |
PATJ | patj | mpz-1 | Snail (MDCK) ZEB-1 (human, breast cancer) |
LIN7A, LIN7B, LIN7C | veli | lin-7 | |
Selected interactors of polarity complexes | |||
INSC | insc | insc-1 | c-Rel (mouse, ESC) Escargot and Snail and Worniu (Drosophila, neuroblast) |
CDH1 | shg | hmr-1 | SNAIL, SLUG, ZEB-1, ZEB-2, Twist1/2, RUNX1, FOXA, p300, Rb, c-Myc, AP-2 (recently reviewed in [22]) ct, Stat92E (Drosophila, spiracle) |
CDH2 | CadN | hmr-1 | NFκB |
PPP2R2/3/5/6 PPP2CA/B PPP2R1A/B | Pp2A-29B, mts, wrd | let-92, paa-1, sur-6, pptr-1/2, rsa-1, cash-1 | CREB, ETS-1, AP-2α, SP-1, SP-3, RXRα/β (mammal, epithelium) |
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Rust, K.; Wodarz, A. Transcriptional Control of Apical-Basal Polarity Regulators. Int. J. Mol. Sci. 2021, 22, 12340. https://doi.org/10.3390/ijms222212340
Rust K, Wodarz A. Transcriptional Control of Apical-Basal Polarity Regulators. International Journal of Molecular Sciences. 2021; 22(22):12340. https://doi.org/10.3390/ijms222212340
Chicago/Turabian StyleRust, Katja, and Andreas Wodarz. 2021. "Transcriptional Control of Apical-Basal Polarity Regulators" International Journal of Molecular Sciences 22, no. 22: 12340. https://doi.org/10.3390/ijms222212340