Next Article in Journal
In Situ Fabrication of High Dielectric Constant Composite Films with Good Mechanical and Thermal Properties by Controlled Reduction
Next Article in Special Issue
Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy
Previous Article in Journal
Possible Side Effects of Polyphenols and Their Interactions with Medicines
Previous Article in Special Issue
Synthesis, Structure and Photochemistry of Dibenzylidenecyclobutanones
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 28
Issue 6
10.3390/molecules28062537
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Macrocycle with Equatorial Coordination Sites Provides New Opportunity for Structure-Diverse Metallacages

by
Yibo Zhao
1,
Yunfeng Lu
2,
Ao Liu
2,
Zhi-Yuan Zhang
2,*,
Chunju Li
2,* and
Andrew C.-H. Sue
1,*
1
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300387, China
2
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China
*
Authors to whom correspondence should be addressed.
Molecules 2023, 28(6), 2537; https://doi.org/10.3390/molecules28062537
Submission received: 13 February 2023 / Revised: 6 March 2023 / Accepted: 8 March 2023 / Published: 10 March 2023
(This article belongs to the Collection Heterocyclic Compounds)
Browse Figures
Versions Notes

Abstract

:
Reported here is the synthesis of a macrocycle with equatorial coordination sites for the construction of self-assembled metallacages. The macrocycle is prepared via a post-modification on the equator of biphen[n]arene. Utilizing this macrocycle as a ligand, three prismatic cages and one octahedral cage were synthesized by regulating the geometric structures and coordination number of metal acceptors. The multi-cavity configuration of prismatic cage was revealed by single-crystal structure. We prove that a macrocycle with equatorial coordination sites can be an excellent building block for synthesizing structure-diverse metallacages. Our results provide a typical example and a general method for the design and synthesis of metallacages.

1. Introduction

Molecular cages are widely utilized in catalysis, drug delivery, smart materials, chemical sensors, etc., due to their diverse building blocks, various geometry, and rich inner cavities [1,2,3,4,5,6]. Rebek and coworkers employed a cylindrical capsule as a nanoscale container for the 1,3-dipolar cycloaddition reaction between phenylazide and phenylacetylene. The cylindrical cavity of the capsule constrains the guests to be arranged in an edge-to-edge manner, resulting in the exclusive formation of the 1,4-triazole product after several days. Tiefenbacher et al. reported the application of an organic molecular cage as a catalyst for the selective hydrolysis of acetal derivatives in organic solvents. Mukherjee et al. demonstrated the utility of a trifacial molecular barrel-type molecular cage as a homogeneous catalyst in the efficient synthesis of xanthenes and their derivatives in aqueous media. Xu and colleagues employed an organic cage as a template to facilitate the synthesis of metal nanoparticles. In 2014, Zhang and coworkers presented a novel approach for the synthesis of gold nanoparticles (AuNPs) with controlled sizes based on a specific covalent organic cage. Therrien et al. demonstrated the formation of triangular prismatic host–guest compounds by self-assembling 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine triangular panels with p-cymene ruthenium building blocks and 2,5-dioxydo-1,4-benzoquinonato bridges in the presence of a pyrenyl derivative (pyrene-R) that was functionalized. Nitschke et al. reported a fascinating collection of aromatic-paneled Fe4L6 cages created through iron(II)-templated subcomponent self-assembly of 2-formylpyridine and C2-symmetric diamine building blocks. The researchers discovered that both the size and the arrangement of the aromatic panels played a critical role in achieving successful encapsulation of large hydrophobic guests, such as fullerenes, polycyclic aromatic hydrocarbons, and steroids. They found that even minor differences in the structure of the subcomponents had obvious effects on the binding abilities of the resulting hosts.
Coordination-driven self-assembly is a simple and efficient method for constructing molecular cages [7,8,9,10,11,12,13]. A series of discrete or consecutive self-assembled metallacages with precisely controllable shapes and sizes (tetrahedron, triangular prisms, and octahedron) have been synthesized by this method [14,15,16]. Fujita and colleagues reported the use of a molecular cage as a nanoreactor for highly stable arenes (including pyrene, triphenylene, phenanthrene, fluoranthene, and perylene) that underwent an intermolecular [2 + 2] photoaddition reaction with N-cyclohexylmaleimide within the nanocavity of this cage. Sun et al. synthesized a water-soluble supramolecular cage by four palladium ions and two ligands. This cage exhibits redox activity and is able to encapsulate aromatic molecules and polyoxometalate catalysts. The well-defined cage possessed a high degree of stability and selectivity. Yan et al. found that the introduction of conformational restrictions on tetraphenylethene units had a significant impact on the structural relaxation in the excited state, as well as on the photophysical behaviors. Wurthner et al. reported a directional bonding approach involving assembling octahedral Fe(II) ions and linear perylene bisimide dyes with 2,2′-bipyridine groups by covalent connecting at the imide positions, resulting in the quantitative formation of a sizeable Fe4(PBI)6 tetrahedron. This remarkable structure had an impressive estimated internal volume of over 950 Å3 and an edge length of 3.9 nm. Jin et al. devised metallacages with cooperative dihydrogen binding sites for highly selectively capture cyclohexane molecules [17]. Generally, metallacages consist of appropriate electron donor ligands and electron-deficient metal-centered acceptors. Most properties of metallacages, such as luminescence, host–guest recognition, and biological toxicity, mainly depend on ligands [18,19,20,21,22]. Therefore, the selection of ligands is a crucial factor in determining the structure, properties, and applications of metallacages. Typically, small molecules are preferred as ligands because of their simple structures and convenient synthetic routes.
In addition to small molecules, macrocyclic hosts have also been used as ligands for metallacages [23,24]. The introduction of macrocycles to metallacages would provide interesting applications such as selective recognition, multi-guest molecule encapsulation, and molecular machines, due to the binding capacity of macrocycle cavities [25,26,27,28]. Therefore, the integration of macrocyclic ligands into metallacages opens up new approaches for the development of advanced materials with tailored properties and applications. Classic macrocyclic arenes such as calixarenes, resorcinarene, and pillararenes, where coordination sites can be easily introduced on their portals, are suitable for synthesizing capsule-like cages. Harrison et al. successfully synthesized a cavitand molecule with four iminodiacetate groups, which was subsequently self-assembled with cobalt(II) or iron(II) ions in water to form octa-anionic capsule molecules. The cobalt capsule has the ability to encapsulate a wide variety of guest molecules, including hydrocarbons, haloalkanes, aromatic compounds, alcohols, and ketones. This discovery showed various potential applications in molecular recognition and selective catalysis. Beer et al. reported a self-assembly of dithiocarbamate-functionalized cavitand molecules with late transition metals including Ni, Pd, Cu, Au, Zn, and Cd. This work expanded the previous findings by demonstrating the self-assembly of functionalized cavitands with a wider range of transition metals, thus opening up new possibilities for the design of complex and functional architectures. Based on a self-recognizable terpyridine-based ligand and Cd(II) ion system, Chan et al. reported a spontaneous heteroleptic complexation strategy. Utilizing this complementary ligand pairing approach, they successfully synthesized three types of nanocapsules, including a dimeric capsule, a Sierpiński triangular prism, and a cubic star, via dynamic complexation reactions between a tetratopic cavitand-based ligand and various multitopic counterparts in the presence of Cd(II) ions. The dimeric capsular assemblies exhibited spacer-length-dependent self-sorting behavior in a four-component system. Furthermore, the precise multicomponent self-assembly of a Sierpiński triangular prism and a cubic star, possessing three and six cavitand-based motifs, respectively, exhibited the potential of this self-assembly methodology for enhancing the architectural complexity of calix[4]resorcinarene-containing metallo-supramolecules. Martinez-Belmonte et al. prepared a novel class of self-assembled cages by conical-shaped carboxylic acid derivatives of calix[4]arene and calix[5]arene ligands and the metallic counterpart of uranyl cation. These cages exhibited hexagonal bipyramidal architectures, resulting from coordination between the uranyl cation and three carboxylate groups located in the equatorial plane. Sue et al. reported AgnL2 metal–organic pillars assembled from pillar[5]arene, which paved the way for the construction of deep-cavity metallocavitands and nanochannels with unique molecular recognition and transportation properties [29,30,31] (Figure 1). We envision that macrocycles bearing equatorial coordination sites would provide a new opportunity for structure-diverse metallacages. However, the introduction of equatorial coordination sites into traditional macrocycles is usually difficult. Firstly, the modification on the skeleton is prohibitive for most macrocyclic compounds; secondly, the stereochemical structures of most macrocycles make it impossible to produce a derivate with equatorial coordination sites [32,33,34,35,36,37]. Therefore, the design and synthesis of macrocycle ligands with equatorial coordination sites remain a formidable challenge.
Herein, we report the synthesis of a macrocyclic compound containing pyridine groups at the equatorial plane for the construction of self-assembled metallacages. As far as we know, this is the first report of synthesizing metallacages from macrocyclic ligands bearing equatorial coordination sites.

2. Results and Discussion

In our previous work, we developed a modular synthetic strategy for functional macrocycles, which realizes the customization of size, functional backbones, and endo-binding sites of macrocycles [38,39,40]. This strategy endows macrocycles with potential applications in gas chromatography, pollutant capture, and physical adsorption separation [41,42]. Benefiting from the modular synthesis and plentiful molecular supplies, we readily synthesized the macrocyclic compound possessing pyridine groups on the outer side of the cavity. As illustrated in Scheme 1, the synthesis process of macrocyclic ligand TP3 can be divided into three steps: firstly, the functional module tribromobenzene is coupled with the 2,5-dimethoxyphenyl reaction module via a Pd-catalyzed Suzuki–Miyaura cross-coupling reaction to obtain the monomer; secondly, the monomer is condensed with polyformaldehyde under the catalysis of Lewis acid boron trifluoride diethyl etherate to obtain TP3-Br; thirdly, the TP3-Br is coupled with pyridine boric acid to obtain the macrocycle TP3. Furthermore, the structure of TP3 was unambiguously confirmed by the single-crystal structure (Scheme 1). TP3 has a regular hexagonal cavity with a diameter of ~11.5 Å (C–C distance). The pyridine groups are located at the equator of the macrocycle molecules with a distance of ~21.0 Å (N–N distance). It is worth noting that the stacking structure of TP3 is not parallel (Figure S33). The N atom of pyridine group forms an intermolecular hydrogen bond with the H atom on the OMe group of adjacent macrocycles (C–H···N 2.9 Å and 3.7 Å).
Subsequently, macrocyclic ligand TP3 was used as a building block for the construction of two types of metallacages with half-sandwich [Ru2(µ-η4-OO∩OO)(η6-p-cymene)2](OTf)2 (OO∩OO = 2,5-dioxido-1,4-benzoquinonato (A1), 5,8-dioxido-1,4-naphtoquinonato (A2), 6,11-dihydroxy-5,12-naphthacenedione (A3)), and cis-Pt-(PEt3)2(OTf)2 (A4) acceptors. As shown in Scheme 1, the prismatic cages M1–M3 were constructed by mixing macrocyclic ligand TP3 with binuclear Ru(II) acceptors A1–A3 in CH2Cl2:CH3OH (v:v = 1:1) under stirring at room temperature for 12 h and then evaporating the solvents. Minor CH3OH was added to the dried residues, followed by the addition of diethyl ether. The resulting precipitates were collected by centrifugation. M1–M3 were obtained in 83–86% yields. Following this method, the octahedral cage M4 was constructed by stirring ligand TP3 with Pt(II) acceptors A4 in CH2Cl2:(CH3)2CO (v:v = 2:1) at room temperature for 24 h. M4 was obtained in 80% yield. All the metallacages were isolated as triflate salts and are highly soluble in common organic solvents like CH3OH, CH3CN, (CH3)2CO, and CH2Cl2. The formation of metallacages M1–M4 was supported by NMR spectrum (1H, 31P (just M4), 13C, COSY, DOSY, and NOESY) and electrospray ionization mass spectrometry (ESI-MS) analyses.
The self-assembly behavior between the acceptors A1–A4 and the ligand TP3 was carefully studied using NMR spectroscopy in CD3CN or CD3OD. The 1H NMR spectra of the resulting metallacages M1–M4 revealed that they possess highly symmetric and discrete structures. Upon the formation of the metallacages, the partial proton signals of the ligand TP3 displayed significant shifts, which can be attributed to the loss of electron density upon ligand-to-metal coordination (Figure 2a and Figure 3a). In addition, diffusion-ordered NMR spectroscopy (DOSY) analysis was conducted, which further confirmed the formation of the metallacages in solution (Figure 2a, Figure 3a, Figures S13 and S23). Specifically, in the DOSY spectra, M1–M4 displayed a single band of signals with a diffusion coefficient (D) of 2.8 × 10−6 cm2/s for M1 in CD3CN, 3.5 × 10−6 cm2/s for M2 in CD3CN, 2.1 × 10−6 cm2/s for M3 in CD3CN, and 2.6 × 10−6 cm2/s for M4 in CD3OD at 298 K, indicating the presence of a single species of metallacages. These results provide strong evidence for the successful formation of the highly symmetric and discrete metallacages through self-assembly between the acceptors and the ligand TP3.
Further confirmation of the formation of the prismatic metallacages M1–M3 and octahedral cage M4 was obtained through ESI-MS studies. The ESI-MS spectrum of M1–M3 displayed peaks corresponding to the assigned [2 + 3] assembly, including peaks with continuous charge states ranging from 3+ to 6+, resulting from the successive loss of the counteranion OTf− (as shown in Figure 2b and Figures S29–S31). Similarly, the ESI-MS results for M4 revealed peaks for the assigned [4 + 6] assembly (Figure 3b and Figure S32). All peaks in the mass spectra were isotopically resolved and agreed well with their calculated theoretical distributions. These results provide further evidence of the successful formation of the desired metallacages. For M1, peaks were observed corresponding to [M1–3OTf]3+ (m/z 1636.6801), [M1–4OTf]4+ (m/z 1190.2698), [M1–5OTf]5+ (m/z 922.4241), and [M1–6OTf]6+ (m/z 743.8596); for M2, peaks were observed corresponding to [M2–3Otf]3+ (m/z 1686.6885), [M2–4Otf]4+ (m/z 1227.7767), [M2–5Otf]5+ (m/z 952.4299), and [M2–6OTf]6+ (m/z 768.8663); for M3, peaks were observed corresponding to [M3–3OTf]3+ (m/z 1787.0522), [M3–4OTf]4+ (m/z 1303.0518), [M3–5OTf]5+ (m/z 1012.6496), and [M3–6OTf]6+ (m/z 819.0487); for M4, peaks were observed corresponding to [M4–4OTf]8+ (m/z 2263.1638), [M4–6OTf]6+ (m/z 1459.1241), and [M4–8OTf]4+ (m/z 1057.1041).
Single-crystal X-ray diffraction analysis further elucidated the structure of prismatic cage M2. The X-ray-quality single crystal of the self-assembly metallacage M2 was obtained as atrovirens cube crystal by vapor diffusion of i-propyl ether into acetonitrile. As illustrated in Figure 2c, the solid-state structure of M2 revealed that two pyridine-based macrocycle TP3 were connected by three ruthenium(II) acceptors. Two macrocyclic molecules form the bottoms of the triangular prism. Interestingly, they are not parallel to each other, which may contribute to an increase in the C–H···π interactions (2.6, 2.8, and 3.0 Å). Some methoxy groups on the macrocyclic molecule inserted into the cavity of another macrocycle via multiple C–H···π interactions. The hydrophobic cavities of the upper and lower were arranged together to form a channel. The Ru(II) acceptor forms the three sides of the triangular prism. They are also not completely vertical. The side length of the bottom surface of the triangular prism is ~25.6 Å (Ru–Ru distance), and the height of the triangular prism is ~8.3 Å (Ru–Ru distance). For the packing structure, adjacent metallacage units are packed in a parallel stacking with a separation of ~5.6 Å (Figure S34); no C–H···π hydrogen bonds can be found.
Despite multiple attempts, it was not possible to obtain a single crystal of M4. Therefore, geometry optimizations were performed using density functional theory (DFT) calculations with the B3LYP/3-21G method. The results of these calculations revealed that M4 has an explicit octahedral conformation. Specifically, the octahedral cage is formed by four macrocyclic ligands (TP3), which form the four faces of the cage, and six Pt(II) acceptors, which form the verticals. The side length of this octahedral cage is 25.7 Å, which is the distance between the Pt atoms. The simulated structure provides a detailed representation of M4’s geometry, which is important for understanding its properties and potential applications. Despite the inability to obtain a single crystal of M4, the DFT calculations provide valuable insights into its structural characteristics.

3. Materials and Methods

All the chemicals used in this study were purchased from commercial sources and were not subjected to any further purification. The nuclear magnetic resonance (NMR) spectra, including 1H, 31P (only for M4), 13C, COSY, DOSY, and NOESY, were recorded on a Bruker Avance 400/600 MHz spectrometer. The chemical shifts in the NMR spectra are reported in parts per million (ppm) relative to the proton resonance resulting from incomplete deuteration of the NMR solvents, which were CD3OD (3.33 ppm for 1H and 49.0 ppm for 13C), CD3CN (1.94 ppm for 1H and 118.3 ppm for 13C), and CDCl3 (7.26 ppm for 1H and 77.2 ppm for 13C). High-resolution electrospray ionization (HR-ESI) mass spectral analyses were performed using the Thermo Fisher Q Exactive™ HF/UltiMate™ 3000 RSLCnano. Matrix Assisted Laser Desorption Ionization (MALDI) mass spectra were performed on Bruker Daltonics UltrafleXtreme time of flight (TOF) equipment. Single crystals suitable for X-ray crystallographic analysis were selected, and their X-ray diffraction intensity data were collected on a rotating anode diffractometer equipped with a hybrid photon counting detector. Graphite-monochromated CuKα radiation with a wavelength of 1.54184 Å was used at a temperature of 200 K. To simulate the geometry optimizations of the metallacage M4, the Gaussian 09 program was used with B3LYP/3-21G computations. The obtained results provide valuable insights into the structure and properties of the metallacage M4, which are important for understanding its potential applications. The use of advanced techniques, such as HR-ESI mass spectrometry and X-ray crystallographic analysis, ensures the accuracy and reliability of the results, while the NMR spectra provide additional information about the chemical environment of the metallacages.
The acceptors [Ru2(µ-η4-OO∩OO)(η6-p-cymene)2](OTf)2 (OO∩OO = 2,5-dioxido-1,4-benzoquinonato (dobq) and 5,8-dioxido-1,4-naphtoquinonato (donq) and 6,11-dihydroxy-5,12-naphthacenedione (dhnc)) and cis-Pt-(PEt3)2(OTf)2 were synthesized under dry nitrogen atmosphere using standard Schlenk technique following the reported procedures [43,44,45,46].
5′-bromo-2,2″,5,5″-tetramethoxy-1,1′:3′,1″-terphenyl: A mixture of tribromobenzene (1.0 g, 3.2 mmol), 2,5-dimethoxybenzene boronic acid (1.28 g, 7.0 mmol), [1,1′-bis(diphenylphosphino)-ferrocene]dichloropalladium (0.12 g, 0.18 mmol), and K2CO3 (1.3 g, 9.6 mmol) was dissolved in 60 mL of a mixed solvent made up of dioxane and water (v/v = 5:1) in a flask. The mixture was stirred at 90 °C for 12 h in a nitrogen atmosphere. After cooling down to room temperature, the solvent was distilled under reduce pressure. The resulting mixture was extracted with CH2Cl2 (3 × 50 mL) and then washed with water and brine successively. The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel (eluent petroleum ether: dichloromethane 2:1, v/v) to afford 5′-bromo-2,2″,5,5″-tetramethoxy-1,1′:3′,1″-terphenyl (0.8 g, 59%). 1H-NMR (400 MHz, CDCl3) δ = (ppm) 7.65 (d, J = 1.5 Hz, 2H), 7.61 (t, J = 1.5 Hz, 1H), 6.95-6.86 (m, 6H), 3.80 (s, 6H), 3.77 (s, 6H). 13C-NMR (100 MHz, CDCl3) δ = (ppm) 153.8, 150. 8, 140.0, 131.1, 130.2, 129.5, 121.6, 116.7, 113.8, 112.7, 56.4, 55.9.
TP3-Br: A solution of 5′-bromo-2,2″,5,5″-tetramethoxy-1,1′:3′,1″-terphenyl (0.50 g, 1.2 mmol) and paraformaldehyde (0.11 g, 3.6 mmol) in 1,2-dichloroethane (100 mL) was prepared, and boron trifluoride etherate (0.10 mL, 1.0 mmol) was added to the solution. The reaction mixture was then stirred at room temperature for 2 h. After completion of the reaction, the mixture was quenched by the addition of 100 mL of saturated NaHCO3 solution. The organic phase was then separated and washed with saturated NaHCO3 solution and brine. The organic layer was dried over anhydrous Na2SO4 and the solvent was removed by evaporation. The resultant residue was purified by column chromatography on silica gel using petroleum ether:dichloromethane (1:1.5, v/v) as the eluent to yield TP3-Br (0.47 g, 30%). 1H-NMR (400 MHz, CDCl3) δ = (ppm) 7.58 (d, J = 1.5 Hz, 6H), 7.57–7.56 (m, 3H), 6.85 (s, 6H), 6.83 (s, 6H), 4.01 (s, 6H), 3.84 (s, 18H), 3.66 (s, 18H). 13C-NMR (100 MHz, CDCl3) δ = (ppm) 151.8, 150.4, 140.2, 130.4, 130.4, 129.9, 127.8, 121.9, 115.0, 113.6, 56.4, 56.3, 30.3.
TP3: A mixture of TP3-Br (0.47 g, 0.35 mmol), pyridine-4-boronic acid (0.43 g, 3.5 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (0.02 g, 0.03 mmol), and Cs2CO3 (0.57 g, 1.75 mmol) were dissolved in 78 mL of a mixed solvent made up of toluene, ethanol and water (v/v/v = 8:4:1) in a flask. The mixture was stirred at 90 °C for 12 h in a nitrogen atmosphere. After cooling down to room temperature, the solvent was distilled under reduce pressure. Resulting mixture was extracted with CH2Cl2 (3 × 50 mL) and then washed with water and brine successively. The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel (eluent dichloromethane: methanol 100:1, v/v) to afford TP3 (0.44 g, 95%). 1H-NMR (600 MHz, CDCl3) δ = (ppm) 8.70 (s, 6H), 7.68 (d, J = 67.1 Hz, 15H), 6.94 (s, 12H), 4.07 (s, 6H), 3.88 (s, 18H), 3.71 (s, 18H). 13C-NMR (100 MHz, CDCl3) δ = (ppm) 151.9, 150.5, 150.2, 149.0, 139.3, 138.1, 132.4, 129.8, 128.7, 126.5, 122.2, 115.0, 113.8, 56.5, 56.4, 30.4. MALDI-TOF MS: C84H75N3O12, calculated for m/z 1317.535; found 1317.596.
General procedure for prismatic metallacages M1–M3: In a 2:3 molar ratio, the ligand TP3 and acceptors [Ru2(µ-η4-OO∩OO)(η6-p-cymene)2]OTf2 (A1–A3) were placed in a 10 mL vial, followed by addition of CH2Cl2 (3 mL) and CH3OH (3 mL). After stirring at ambient temperature for 24 h, the solution was concentrated to 0.5 mL. The self-assembly products were isolated via precipitation by addition of diethyl ether into concentrated solution, washed twice with diethyl ether and dried under vacuum.
M1: Reaction scale: A1 (9.2 mg, 0.01 mmol) and TP3 (9.2 mg, 0.007 mmol). Compound M1 was obtained as a red powder, 12.3 mg, 83% yield. 1H-NMR (400 MHz, CD3CN) δ = (ppm) 8.26 (s, 12H), 7.81 (s, 12H), 7.69 (s, 12H), 7.61 (s, 6H), 6.83 (s, 24H), 5.91 (s, 12H), 5.79 (s, 6H), 5.69 (s, 12H), 3.87 (s, 12H), 3.57 (s, 36H), 3.43 (s, 36H), 2.96–2.75 (m, 6H), 2.07 (s, 18H), 1.34 (d, J = 4.9 Hz, 36H). 13C-NMR (100 MHz, CD3CN) δ = (ppm) 185.2, 153.8, 152.6, 151.8, 150.4, 140.4, 135.7, 134.2, 130.3, 128.7, 127.4, 124.6, 115.7, 113.8, 104.5, 102.2, 99.1, 84.6, 82.7, 56.6, 56.5, 32.1, 31.1, 22.4, 18.2. ESI-MS: m/z calculated for [M1–4OTf]8+: 1190.2630; found 1190.2698.
M2: Reaction scale: A2 (9.6 mg, 0.01 mmol) and TP3 (9.2 mg, 0.007 mmol). Compound M2 was obtained as a green powder, 13.1 mg, 85% yield. 1H-NMR (400 MHz, CD3CN) δ = (ppm) 8.38 (t, J = 6.3 Hz, 12H), 7.72 (d, J = 6.5 Hz, 12H), 7.63 (d, J = 1.1 Hz, 12H), 7.59 (d, J = 5.9 Hz, 6H), 7.23 (d, J = 7.0 Hz, 12H), 6.88-6.73 (m, 24H), 5.70 (t, J = 5.9 Hz, 12H), 5.50 (t, J = 5.9 Hz, 12H), 3.85 (d, J = 11.1 Hz, 12H), 3.57 (s, 36H), 3.44 (d, J = 16.4 Hz, 36H), 2.90–2.67 (m, 6H), 2.10 (d, J = 6.9 Hz, 18H), 1.31 (t, J = 7.5 Hz, 36H). 13C-NMR (100 MHz, CD3CN) δ = (ppm) 171.9, 153.0, 152.6, 151.9, 151.1, 140.3, 138.4, 136.1, 134.0, 130.3, 128.8, 127.4, 124.5, 115.8, 114.2, 112.4, 104.5, 100.2, 85.1, 84.0, 56.7, 56.5, 31.4, 31.1, 22.3, 17.3. ESI-MS: m/z calculated for [M2–4OTf]8+: 1227.7747; found 1227.7767.
M3: Reaction scale: A3 (10.6 mg, 0.01 mmol) and TP3 (9.2 mg, 0.007 mmol). Compound M3 was obtained as a dark-blue powder, 14.1 mg, 86% yield. 1H-NMR (400 MHz, CD3OD) δ = (ppm) 8.78 (s, 12H), 8.57 (d, J = 5.4 Hz, 12H), 7.98 (s, 12H), 7.69 (d, J = 5.2 Hz, 12H), 7.54 (s, 12H), 7.42 (s, 6H), 6.66 (d, J = 5.1 Hz, 24H), 6.02 (d, J = 5.8 Hz, 12H), 5.78 (d, J = 5.8 Hz, 12H), 3.83 (dd, J = 24.4, 14.6 Hz, 12H), 3.57-3.47 (m, 36H), 3.31 (s, 36H), 3.01–2.93 (m, 6H), 2.23 (s, 18H), 1.34 (dd, J = 23.2, 6.6 Hz, 36H). 13C-NMR (100 MHz, CD3OD) δ = (ppm) 170.6, 153.2, 151.5, 140.7, 135.1, 134.3, 130.9, 129.7, 128.4, 127.2, 124.5, 116.3, 114.2, 104.9, 101.0, 85.1, 83.6, 66.9, 56.9, 56.5, 32.1, 22.6, 17.9, 15.4. ESI-MS: m/z calculated for [M3–4OTf]8+: 1303.0490; found 1303.0518.
M4: At a 4:6 molar ratio, the platinum complex A4 (5.3 mg, 0.007 mmol) and TP3 (6.4 mg, 0.005 mmol) were placed in a 10 mL vial, followed by addition of CH2Cl2 (3 mL) and (CH3)2CO (3 mL). After stirring at ambient temperature for 24 h, the solution was concentrated. The self-assembly products were isolated via precipitation by adding diethyl ether into the concentrated solution, washing twice with diethyl ether, and drying under vacuum to obtain product M4 (20.1 mg, 60% yield). 1H-NMR (400 MHz, CD3OD) δ = (ppm) 8.64 (d, J = 14.1 Hz, 24H), 8.17–7.59 (m, 60H), 6.97 (s, 48H), 4.01 (s, 24H), 3.86 (s, 72H), 3.69 (s, 72H), 2.17 (s, 36H), 1.85 (s, 36H), 1.33–1.18 (m, 108H). ESI-MS: m/z calculated for [M4–4OTf]8+: 2263.1615; found 2263.1638.

4. Conclusions

In summary, we successfully synthesized a macrocycle TP3 with pyridine units on the equator via a post-modification of biphenarene. Benefiting from the equatorial coordination sites, the macrocycle could be an excellent ligand for the construction of four novel prismatic/octahedral cages M1–M4 via coordination-driven self-assembly with Ru(II) and Pt(II) building acceptors. All these metallacages were fully characterized by NMR and ESI-MS spectroscopic studies. Moreover, the multi-cavity configuration of the prismatic cage was proven by X-ray crystallographic analysis. This work enriches the toolbox of macrocycle ligands and provides a general method for the design and synthesis of structure-diverse metallacages. More macrocycles with equatorial coordination sites can be synthesized, various macrocycle-based metallacages can be assembled, and further functions and applications can be explored.

Supplementary Materials

The following supporting information can be downloaded at https://www.mdpi.com/article/10.3390/molecules28062537/s1. Figure S1. 1H NMR spectrum (400 MHz, CDCl3, 298 K) of 5′-bromo-2,2″,5,5″-tetramethoxy-1,1′:3′,1″-terphenyl. Figure S2. 13C NMR spectrum (100 MHz, CDCl3, 298 K) of 5′-bromo-2,2″,5,5″-tetramethoxy-1,1′:3′,1″-terphenyl. Figure S3. 1H NMR spectrum (400 MHz, CDCl3, 298 K) of TP3-Br. Figure S4. 13C NMR spectrum (100 MHz, CDCl3, 298 K) of TP3-Br. Figure S5. 1H NMR spectrum (600 MHz, CDCl3, 298 K) of TP3. Figure S6. 13C NMR spectrum (100 MHz, CDCl3, 298 K) of TP3-Br. Figure S7. MALDI-TOF MS of TP3-Br. Figure S8. 2D COSY spectrum (400 MHz, CDCl3, 298 K) of TP3-Br. Figure S9. 1H NMR spectrum (400 MHz, CD3CN, 298 K) of M1. Figure S10. 13C NMR spectrum (100 MHz, CD3CN, 298 K) of M1. Figure S11. 2D COSY spectrum (400 MHz, CD3CN, 298 K) of M1. Figure S12. 2D NOESY spectrum (400 MHz, CD3CN, 298 K) of M1. Figure S13. DOSY spectrum (400 MHz, CD3CN, 298 K) of M1. Figure S14. 1H NMR spectrum (400 MHz, CD3CN, 298 K) of M2. Figure S15. 13C NMR spectrum (100 MHz, CD3CN, 298 K) of M2. Figure S16. 2D COSY spectrum (400 MHz, CD3CN, 298 K) of M2. Figure S17. 2D NOESY spectrum (400 MHz, CD3CN, 298 K) of M2. Figure S18. DOSY spectrum (400 MHz, CD3CN, 298 K) of M2. Scheme S3. Synthetic routes for the M3. Figure S19. 1H NMR spectrum (400 MHz, CD3OD, 298 K) of M3. Figure S20. 13C NMR spectrum (100 MHz, CD3OD, 298 K) of M3. Figure S21. 2D COSY spectrum (400 MHz, CD3OD, 298 K) of M3. Figure S22. 2D NOESY spectrum (400 MHz, CD3OD, 298 K) of M3. Figure S23. DOSY spectrum (400 MHz, CD3CN, 298 K) of M3. Figure S24. 1H NMR spectrum (400 MHz, CD3OD, 298 K) of M4. Figure S25. 31P{1H} NMR (162 MHz, CD3OD, 25 °C) spectrum of M4. Figure S26. 2D COSY spectrum (400 MHz, CD3OD, 298 K) of M4. Figure S27. 2D NOESY spectrum (400 MHz, CD3OD, 298 K) of M4. Figure S28. DOSY spectrum (400 MHz, CD3OD, 298 K) of M4. Figure S29. ESI-MS spectra of M1. Figure S30. ESI-MS spectra of M2. Figure S31. ESI-MS spectra of M3. Figure S32. ESI-MS spectra of M4. Figure S33. Packing diagram of TP3 view along the (a) a-axis, (b) b-axis, and (c) c-axis. Figure S34. Packing diagram of M2 view along the (a) a-axis, (b) b-axis, and (c) c-axis. Table S1. Crystal data of TP3. Table S2. Crystal data of M2. Scheme S1. Synthetic routes for the M1. Scheme S2. Synthetic routes for the M2.

Author Contributions

Conceptualization, C.L. and Y.Z.; methodology, Y.Z.; validation, Y.Z., Y.L. and A.L.; formal analysis, C.L. and Z.-Y.Z.; investigation, Y.Z.; resources, C.L.; data curation, Y.Z. and Y.L.; writing—original draft preparation, Z.-Y.Z. and Y.Z.; writing—review and editing, C.L. and A.C.-H.S.; visualization, Y.Z.; supervision, A.C.-H.S.; project administration, Y.Z. and Z.-Y.Z.; funding acquisition, C.L. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by the National Natural Science Foundation of China (21971192, 21772118, 21871208, and 22011530163).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data can be made available upon reasonable request.

Acknowledgments

The authors greatly appreciate the structural optimization by Wangjian Fang (Tianjin University) and warmly thank Shunshun Li (Tianjin University) for drawing the cartoon representations.

Conflicts of Interest

The authors declare no conflict of interest.

Sample Availability

Samples of the compounds are available from the authors upon reasonable request.

References

  1. Saha, R.; Mondal, B.; Mukherjee, P.S. Molecular Cavity for Catalysis and Formation of Metal Nanoparticles for Use in Catalysis. Chem. Rev. 2022, 122, 12244–12307. [Google Scholar] [CrossRef] [PubMed]
  2. Liu, C.; Zhang, Y.; An, Q. Functional Material Systems Based on Soft Cages. Chem. Asian J. 2021, 16, 1198–1215. [Google Scholar] [CrossRef] [PubMed]
  3. Montà-González, G.; Sancenón, F.; Martínez-Máñez, R.; Martí-Centelles, V. Purely Covalent Molecular Cages and Containers for Guest Encapsulation. Chem. Rev. 2022, 122, 13636–13708. [Google Scholar] [CrossRef] [PubMed]
  4. Fang, S.; Wang, M.; Wu, Y.; Guo, Q.-H.; Li, E.; Li, H.; Huang, F. Cagearenes: Synthesis, characterization, and application for programmed vapour release. Chem. Sci. 2022, 13, 6254–6261. [Google Scholar] [CrossRef]
  5. Zhu, Z.; Tian, C.; Sun, Q. Coordination-Assembled Molecular Cages with Metal Cluster Nodes. Chem. Rec. 2020, 21, 498–522. [Google Scholar] [CrossRef]
  6. Dale, E.J.; Vermeulen, N.A.; Juricek, M.; Barnes, J.C.; Young, R.M.; Wasielewski, M.R.; Stoddart, J.F. Supramolecular Explorations: Exhibiting the Extent of Extended Cationic Cyclophanes. Acc. Chem. Res. 2016, 49, 262–273. [Google Scholar] [CrossRef] [Green Version]
  7. Cook, T.R.; Zheng, Y.-R.; Stang, P.J. Metal–Organic Frameworks and Self-Assembled Supramolecular Coordination Complexes: Comparing and Contrasting the Design, Synthesis, and Functionality of Metal–Organic Materials. Chem. Rev. 2013, 113, 734–777. [Google Scholar] [CrossRef] [Green Version]
  8. Gao, W.-X.; Feng, H.-J.; Guo, B.-B.; Lu, Y.; Jin, G.-X. Coordination-Directed Construction of Molecular Links. Chem. Rev. 2020, 120, 6288–6325. [Google Scholar] [CrossRef]
  9. Li, H.; Yao, Z.-J.; Liu, D.; Jin, G.-X. Multi-component coordination-driven self-assembly toward heterometallic macrocycles and cages. Coord. Chem. Rev. 2015, 293, 139–157. [Google Scholar] [CrossRef]
  10. Yu, X.; Guo, C.; Lu, S.; Chen, Z.; Wang, H.; Li, X. Terpyridine-Based 3D Discrete Metallosupramolecular Architectures. Macromol. Rapid Commun. 2022, 43, e2200004. [Google Scholar] [CrossRef]
  11. Zhao, J.; Zhou, Z.; Li, G.; Stang, P.J.; Yan, X. Light-emitting self-assembled metallacages. Natl. Sci. Rev. 2021, 8, nwab045. [Google Scholar] [CrossRef]
  12. Mukherjee, S.; Mukherjee, P.S. Template-free multicomponent coordination-driven self-assembly of Pd(II)/Pt(II) molecular cages. Chem. Commun. 2014, 50, 2239–2248. [Google Scholar] [CrossRef] [Green Version]
  13. Gao, W.-X.; Zhang, H.-N.; Jin, G.-X. Supramolecular catalysis based on discrete heterometallic coordination-driven metallacycles and metallacages. Coord. Chem. Rev. 2019, 386, 69–84. [Google Scholar] [CrossRef]
  14. Sun, Y.; Chen, C.; Liu, J.; Stang, P.J. Recent developments in the construction and applications of platinum-based metallacycles and metallacages via coordination. Chem. Soc. Rev. 2020, 49, 3889–3919. [Google Scholar] [CrossRef]
  15. McTernan, C.T.; Davies, J.A.; Nitschke, J.R. Beyond Platonic: How to Build Metal-Organic Polyhedra Capable of Binding Low-Symmetry, Information-Rich Molecular Cargoes. Chem. Rev. 2022, 122, 10393–10437. [Google Scholar] [CrossRef]
  16. Cheng, Y.; Zhang, Z.; Duan, X.; Zhang, M. cis-Dipyridyl porphyrin-based multicomponent organoplatinum(II) bismetallacycles for photocatalytic oxidation. Dalton Trans. 2022, 51, 16517–16521. [Google Scholar] [CrossRef]
  17. Cui, P.-F.; Liu, X.-R.; Lin, Y.-J.; Li, Z.-H.; Jin, G.-X. Highly Selective Separation of Benzene and Cyclohexane in a Spatially Confined Carborane Metallacage. J. Am. Chem. Soc. 2022, 144, 6558–6565. [Google Scholar] [CrossRef]
  18. Chang, X.; Lin, S.; Wang, G.; Shang, C.; Wang, Z.; Liu, K.; Fang, Y.; Stang, P.J. Self-Assembled Perylene Bisimide-Cored Trigonal Prism as an Electron-Deficient Host for C(60) and C(70) Driven by “Like Dissolves Like”. J. Am. Chem. Soc. 2020, 142, 15950–15960. [Google Scholar] [CrossRef]
  19. Guo, Z.; Li, G.; Wang, H.; Zhao, J.; Liu, Y.; Tan, H.; Li, X.; Stang, P.J.; Yan, X. Drum-like Metallacages with Size-Dependent Fluorescence: Exploring the Photophysics of Tetraphenylethylene under Locked Conformations. J. Am. Chem. Soc. 2021, 143, 9215–9221. [Google Scholar] [CrossRef]
  20. Li, Y.; Rajasree, S.S.; Lee, G.Y.; Yu, J.; Tang, J.-H.; Ni, R.; Li, G.; Houk, K.N.; Deria, P.; Stang, P.J. Anthracene–Triphenylamine-Based Platinum(II) Metallacages as Synthetic Light-Harvesting Assembly. J. Am. Chem. Soc. 2021, 143, 2908–2919. [Google Scholar] [CrossRef]
  21. Takezawa, H.; Murase, T.; Resnati, G.; Metrangolo, P.; Fujita, M. Recognition of Polyfluorinated Compounds Through Self-Aggregation in a Cavity. J. Am. Chem. Soc. 2014, 136, 1786–1788. [Google Scholar] [CrossRef] [PubMed]
  22. Fan, Y.; Li, C.; Bai, S.; Ma, X.; Yang, J.; Guan, X.; Sun, Y. NIR-II Emissive Ru(II) Metallacycle Assisting Fluorescence Imaging and Cancer Therapy. Small 2022, 18, e2201625. [Google Scholar] [CrossRef] [PubMed]
  23. Kobayashi, K.; Yamanaka, M. Self-assembled capsules based on tetrafunctionalized calix[4]resorcinarene cavitands. Chem. Soc. Rev. 2014, 44, 449–466. [Google Scholar] [CrossRef] [PubMed]
  24. Haino, T.; Kobayashi, M.; Fukazawa, Y. Guest Encapsulation and Self-Assembly of a Cavitand-Based Coordination Capsule. Chem. A Eur. J. 2006, 12, 3310–3319. [Google Scholar] [CrossRef] [PubMed]
  25. Wang, Y.; Ping, G.; Li, C. Efficient complexation between pillar[5]arenes and neutral guests: From host–guest chemistry to functional materials. Chem. Commun. 2016, 52, 9858–9872. [Google Scholar] [CrossRef]
  26. Nie, H.; Wei, Z.; Ni, X.-L.; Liu, Y. Assembly and Applications of Macrocyclic-Confinement-Derived Supramolecular Organic Luminescent Emissions from Cucurbiturils. Chem. Rev. 2022, 122, 9032–9077. [Google Scholar] [CrossRef]
  27. Sun, Y.; Guo, F.; Zuo, T.; Hua, J.; Diao, G. Stimulus-responsive light-harvesting complexes based on the pillararene-induced co-assembly of beta-carotene and chlorophyll. Nat. Commun. 2016, 7, 12042. [Google Scholar] [CrossRef] [Green Version]
  28. Xue, W.; Zavalij, P.Y.; Isaacs, L. Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water. Angew. Chem. Int. Ed. 2020, 59, 13313–13319. [Google Scholar] [CrossRef]
  29. Wan, X.; Li, S.; Tian, Y.; Xu, J.; Shen, L.-C.; Zuilhof, H.; Zhang, M.; Sue, A.C.-H. Twisted pentagonal prisms: AgnL2 metal-organic pillars. Chem 2022, 8, 2136–2147. [Google Scholar] [CrossRef]
  30. Pasquale, S.; Sattin, S.; Escudero-Adán, E.C.; Martínez-Belmonte, M.; de Mendoza, J. Giant regular polyhedra from calixarene carboxylates and uranyl. Nat. Commun. 2012, 3, 785. [Google Scholar] [CrossRef] [Green Version]
  31. He, L.; Wang, S.-C.; Lin, L.-T.; Cai, J.-Y.; Li, L.; Tu, T.-H.; Chan, Y.-T. Multicomponent Metallo-Supramolecular Nanocapsules Assembled from Calix[4]resorcinarene-Based Terpyridine Ligands. J. Am. Chem. Soc. 2020, 142, 7134–7144. [Google Scholar] [CrossRef]
  32. Pan, Y.-C.; Hu, X.-Y.; Guo, D.-S. Biomedical Applications of Calixarenes: State of the Art and Perspectives. Angew. Chem. Int. Ed. 2020, 60, 2768–2794. [Google Scholar] [CrossRef]
  33. Shimoyama, D.; Haino, T. Feet-to-Feet-Connected Multitopic Resorcinarene Macrocycles. Asian J. Org. Chem. 2020, 9, 1718–1725. [Google Scholar] [CrossRef]
  34. Wang, K.; Jordan, J.H.; Velmurugan, K.; Tian, X.; Zuo, M.; Hu, X.; Wang, L. Role of Functionalized Pillararene Architectures in Supramolecular Catalysis. Angew. Chem. Int. Ed. 2020, 60, 9205–9214. [Google Scholar] [CrossRef]
  35. Xiao, C.; Wu, W.; Liang, W.; Zhou, D.; Kanagaraj, K.; Cheng, G.; Su, D.; Zhong, Z.; Chruma, J.J.; Yang, C. Redox-Triggered Chirality Switching and Guest-Capture/Release with a Pillar[6]arene-Based Molecular Universal Joint. Angew. Chem. Int. Ed. 2020, 59, 8094–8098. [Google Scholar] [CrossRef]
  36. Fa, S.; Sakata, Y.; Akine, S.; Ogoshi, T. Non-Covalent Interactions Enable the Length-Controlled Generation of Discrete Tubes Capable of Guest Exchange. Angew. Chem. Int. Ed. 2020, 59, 9309–9313. [Google Scholar] [CrossRef]
  37. Shi, Q.; Wang, X.; Liu, B.; Qiao, P.; Li, J.; Wang, L. Macrocyclic host molecules with aromatic building blocks: The state of the art and progress. Chem. Commun. 2021, 57, 12379–12405. [Google Scholar] [CrossRef]
  38. Xu, K.; Zhang, Z.-Y.; Yu, C.; Wang, B.; Dong, M.; Zeng, X.; Gou, R.; Cui, L.; Li, C. A Modular Synthetic Strategy for Functional Macrocycles. Angew. Chem. Int. Ed. 2020, 59, 7214–7218. [Google Scholar] [CrossRef]
  39. Zhang, Z.Y.; Li, C. Biphen[n]arenes: Modular Synthesis, Customizable Cavity Sizes, and Diverse Skeletons. Acc. Chem. Res. 2022, 55, 916–929. [Google Scholar] [CrossRef]
  40. Xu, K.; Zhang, Z.-Y.; Zhou, Z.; Li, C. Prospering the biphen[n]arenes family by tailoring reaction modules. Chin. Chem. Lett. 2021, 33, 2451–2454. [Google Scholar] [CrossRef]
  41. Zhao, X.; Liu, Y.; Zhang, Z.Y.; Wang, Y.; Jia, X.; Li, C. One-Pot and Shape-Controlled Synthesis of Organic Cages. Angew. Chem. Int. Ed. 2021, 60, 17904–17909. [Google Scholar] [CrossRef] [PubMed]
  42. Li, B.; Wang, B.; Huang, X.; Dai, L.; Cui, L.; Li, J.; Jia, X.; Li, C. Terphen[n]arenes and Quaterphen[n]arenes (n = 3–6): One-Pot Synthesis, Self-Assembly into Supramolecular Gels, and Iodine Capture. Angew. Chem. Int. Ed. 2019, 58, 3885–3889. [Google Scholar] [CrossRef] [PubMed]
  43. Barry, N.P.E.; Therrien, B. Host−Guest Chemistry in the Hexanuclear (Arene)ruthenium Metalla-Prismatic Cage [Ru6(pcymene)6(tpt)2(dhnq)3]6+. Eur. J. Inorg. Chem. 2009, 31, 4695–4700. [Google Scholar] [CrossRef] [Green Version]
  44. Barry, N.; Furrer, J.; Therrien, B. In- and Out-of-Cavity Interactions by Modulating the Size of Ruthenium Metallarectangles. Helv. Chim. Acta 2010, 93, 1313–1328. [Google Scholar] [CrossRef] [Green Version]
  45. Yan, H.; Süss-Fink, G.; Neels, A.; Stoeckli-Evans, H. Mono-, di- and tetra-nuclear p-cymeneruthenium complexes containing oxalato ligands. J. Chem. Soc. Dalton Trans. 1997, 22, 4345–4350. [Google Scholar] [CrossRef] [Green Version]
  46. Stang, P.J.; Cao, D.H.; Saito, S.; Arif, A.M. Self-Assembly of Cationic, Tetranuclear, Pt(II) and Pd(II) Macrocyclic Squares. x-ray Crystal Structure of [Pt2+(dppp)(4,4′-bipyridyl).cntdot.2-OSO2CF3]4. J. Am. Chem. Soc. 1995, 117, 6273–6283. [Google Scholar] [CrossRef]
Molecules 28 02537 g001 550
Figure 1. Schematic illustration of macrocyclic ligands with portal coordination sites (reported work) and equatorial coordination sites (this work) for the construction of coordination-driven self-assembly metallacages.
Figure 1. Schematic illustration of macrocyclic ligands with portal coordination sites (reported work) and equatorial coordination sites (this work) for the construction of coordination-driven self-assembly metallacages.
Molecules 28 02537 g001
Molecules 28 02537 sch001 550
Scheme 1. The synthesis and crystal structure of macrocyclic ligand (TP3) with equatorial coordination sites (top). TP3 has a regular hexagonal cavity with a diameter of ~11.5 Å (C–C distance) and pyridine distance of ~21.0 Å (N–N distance). Cartoon representations of the assembly of [2 + 3] prismatic cages [4 + 6] and octahedron cage by macrocyclic ligand TP3 and metal acceptors Ru(II) and Pt(II) (bottom).
Scheme 1. The synthesis and crystal structure of macrocyclic ligand (TP3) with equatorial coordination sites (top). TP3 has a regular hexagonal cavity with a diameter of ~11.5 Å (C–C distance) and pyridine distance of ~21.0 Å (N–N distance). Cartoon representations of the assembly of [2 + 3] prismatic cages [4 + 6] and octahedron cage by macrocyclic ligand TP3 and metal acceptors Ru(II) and Pt(II) (bottom).
Molecules 28 02537 sch001
Molecules 28 02537 g002 550
Figure 2. (a) 1H and DOSY NMR spectra of ligand TP3 and metallacage M2 in CD3CN. (b) Calculated (blue) and experimental (red) ESI-MS of M2. (c) Chemical structure and crystal structure of M2 from the side views. The solvents, counterions, H atoms, and methyl/isopropyl in cymene are omitted for clarity. Color code: gray = C; red = O; blue = N; green = Ru; gold = pyridine units.
Figure 2. (a) 1H and DOSY NMR spectra of ligand TP3 and metallacage M2 in CD3CN. (b) Calculated (blue) and experimental (red) ESI-MS of M2. (c) Chemical structure and crystal structure of M2 from the side views. The solvents, counterions, H atoms, and methyl/isopropyl in cymene are omitted for clarity. Color code: gray = C; red = O; blue = N; green = Ru; gold = pyridine units.
Molecules 28 02537 g002
Molecules 28 02537 g003 550
Figure 3. (a) 1H and DOSY NMR spectra of ligand TP3 and metallacage M4 in CD3OD. (b) Calculated (blue) and experimental (red) ESI-MS of M4. (c) Optimized structure of M4 from the top and side views. The solvents, counterions, and H atoms are omitted for clarity. Color code: gray = C; red = O; blue = N; dark green = P; green = Pt; gold = pyridine units.
Figure 3. (a) 1H and DOSY NMR spectra of ligand TP3 and metallacage M4 in CD3OD. (b) Calculated (blue) and experimental (red) ESI-MS of M4. (c) Optimized structure of M4 from the top and side views. The solvents, counterions, and H atoms are omitted for clarity. Color code: gray = C; red = O; blue = N; dark green = P; green = Pt; gold = pyridine units.
Molecules 28 02537 g003
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Zhao, Y.; Lu, Y.; Liu, A.; Zhang, Z.-Y.; Li, C.; Sue, A.C.-H. Macrocycle with Equatorial Coordination Sites Provides New Opportunity for Structure-Diverse Metallacages. Molecules 2023, 28, 2537. https://doi.org/10.3390/molecules28062537

AMA Style

Zhao Y, Lu Y, Liu A, Zhang Z-Y, Li C, Sue AC-H. Macrocycle with Equatorial Coordination Sites Provides New Opportunity for Structure-Diverse Metallacages. Molecules. 2023; 28(6):2537. https://doi.org/10.3390/molecules28062537

Chicago/Turabian Style

Zhao, Yibo, Yunfeng Lu, Ao Liu, Zhi-Yuan Zhang, Chunju Li, and Andrew C.-H. Sue. 2023. "Macrocycle with Equatorial Coordination Sites Provides New Opportunity for Structure-Diverse Metallacages" Molecules 28, no. 6: 2537. https://doi.org/10.3390/molecules28062537

Article Metrics

Back to TopTop