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Molecules
Volume 27
Issue 22
10.3390/molecules27227901
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Article
Peer-Review Record

Hydrogels from the Assembly of SAA/Elastin-Inspired Peptides Reveal Non-Canonical Nanotopologies

Molecules 2022, 27(22), 7901; https://doi.org/10.3390/molecules27227901
by Alessandra Scelsi 1, Brigida Bochicchio 1, Andrew M. Smith 2, Antonio Laezza 1, Alberto Saiani 2 and Antonietta Pepe 1,*
Reviewer 1: Anonymous
Reviewer 2:
Demetra Giuri
Molecules 2022, 27(22), 7901; https://doi.org/10.3390/molecules27227901
Submission received: 3 October 2022 / Revised: 31 October 2022 / Accepted: 10 November 2022 / Published: 15 November 2022
(This article belongs to the Special Issue Exclusive Papers of the Editorial Board Members (EBMs) of the Bioorganic Chemistry Section of Molecules (2022))

Round 1

Reviewer 1 Report

In the paper “Hydrogels from the co-assembly of SAA/elastin-inspired peptides reveal non-canonical nanotopology”, Alessandra Scelsi and co-workers investigated the co-assembly behavior of different peptides in detail. This work is very interesting and can be published in Molecules after a minor revision.

Comments:

1. Will the second structure of formed fibers be changed along with the increasing of concentration of peptides? Please give CD data.

2. In the experimental section, the authors displayed that different concentration of P5 and P21 can form hydrogels with various mechanical properties. Therefore, how many the peptides take part in the co-assembling process to form fibers? It is better to give the composition of fibers.

3. Did the preparation process of sample of AFM and SEM have effect on the morphology of formed hydrogels? It is suggested to prepare the samples by lyophilization. 

4. Please give the method how to measure the width of fibers.

5. The unit of scale bars in Figure 3 is not clear enough, please revise them.

6. It is better to apply density functional theory (DFT) to simulate the co-assembly of different peptides

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report


Comments for author File: Comments.pdf

Author Response

Please see the attachment

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

The authors have replied to all my comments and addressed them carefully and properly. I recommend the publication of the reviewed version.

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