Biological Role of Gellan Gum in Improving Scaffold Drug Delivery, Cell Adhesion Properties for Tissue Engineering Applications
Abstract
:1. Introduction
2. Gellan Gum in Drug Delivery
3. Gellan Gum Cell Adhesion Properties
4. Conclusion
Funding
Conflicts of Interest
References
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Sl No | GG Composites | Applications | Reference |
---|---|---|---|
1 | Xanthan gum (XG) -HAp | Bone tissue engineering | [90] |
2 | GG-XG-hyaluronan | Bone tissue engineering | [91] |
3 | GG/Starch | Drug delivery system | [92] |
4 | GG/alpha amylase | Pharmaceutical and biomedical | [5] |
5 | GG/PVA-Ofloxacin | Gastroretentive/mucoadhesive drug delivery | [85] |
6 | GG/kappa-carrageenan | Drugs on the ocular surface | [93] |
7 | GG/Chitosan | Nasal insert, antifungal agent, coatings, wound healing, antibiotic | [47,94,95,96] [14] |
8 | GG/kappa-carrageenan/alginates | Antifungal and antimicrobial drugs | [97] |
9 | GG/XG | Anti-adhesive | [98] |
10 | GG/pectin | Drug delivery | [15] |
11 | GG/agar | Biomedical applications | [99] |
12 | GG methacrylate/gelatin methacrylamide | In scaffolds for load-bearing tissues | [91] |
13 | GG/alginate | Sustained drug release | [16] |
14 | GG/titanium dioxide nanoparticles | Wound healing | [100] |
15 | GG/HAp | Bone, vasculature | [31,101] [102] |
16 | GG/Gelatin/genipin | material | [103] |
17 | GG/PLGA microsphere | Vertebra | [101] |
18 | GG/Gold nanorods | Bone | [104] |
19 | GG/Bioglass | Bone | [32,105] |
20 | GG/Graphine oxide | Scaffold | [106] |
21 | GG/HAGG/LAGG blends methacrylation/HA | Intervertebral discs | [106] |
22 | GG//methacrylation/GG microsphere/gelatin | Load bearing tissue | [107] |
23 | GG/methacrylation | Intervertebral discs, TE, cartilage repair | [58,108,109] |
24 | GG/Cinnamate | Wound healing | [110] |
25 | GG/Methacrylated gelatin | Cartilage | [111] |
26 | GG/HA | Skin repair/vascularization/cartilage regeneration | [102] [35] |
27 | GG/Laponite beads | Drug release | [112] |
28 | GG/ gum cordia | Drug delivery | [99] |
29 | GG/apigenin | Drug release | [113] |
30 | GG/avidin/boptinylated adhesive | Cell culture | [114] |
31 | GG/HAp/Lactoferrin | Bone tissue engineering | [115,116] |
32 | GG/AuNPs | Anti-cancer drug delivery | [75] |
33 | GG/AuNPs/DOX | Anti-cancer drug delivery | [76] |
34 | GG/AgNPs | Antibacterial, cytotoxic | [77] |
35 | GG/AuNRs | Intercellular drug delivery and imaging | [78] |
36 | GG/poloxamer 407/carbopol 934P) | Controlled delivery and antibacterial activity | [117] |
37 | GG/Lactoferrin | Bone Tissue Engineering | [115] |
38 | GG/insulin | Drug delivery | [82] |
39 | GG/poly(vinyl) alcohol | Tissue Engineering | [118] |
40 | GG/levofloxacin hemihydrate | Ophthalmic solution | [84] |
41 | GG/Polyvinylpyrrolidone (PVP) | Sustained release | [119] |
42 | Gelatin-grafted-GG-hydrogel microsphere | Cell encapsulation and delivery | [120] |
43 | GG hydrogel | Cartilage Tissue Engineering | [23], [121] |
43 | GG/fibrin/agarose | Cartilage regeneration | [122] |
44 | Ionic crosslinked methacrylated GG/Silk | Meniscus tissue engineering | [123] |
45 | GG/Polydopamine | Bone tissue engineering | [105] |
46 | GG/Collagen I, Beta -TCP | Bone graft material | [124] |
47 | GG-MA hydrogels | Intervertebral Disc | [28,106] [125] |
48 | GG/RGD | Cell adhesion, proliferation | [120] |
49 | GG/ UV crosslinked gelatin-methacryloyl (geMA) | Cartilage grafts bioprinting | [126,127] |
50 | GG/acrylamide grafted | Sustained release | [128] |
51 | GG/ dextran sulfates/ cellulose sulfate | Drug delivery | [129] |
52 | GG/polyvinylalcoho | Beta-blocker | [130] |
53 | GG/alginate | Antibiotic, Antinflammatory | [73,131] |
54 | GG/polyvinylalcohol | Antibiotic | [132] |
55 | GG/hyaluronic acid ester/polyvinylalcohol | Wound healing | [133] |
56 | GG/chitosan/PEG | Wound healing | [134] |
57 | GG/glucosamine | Oral cancer treatment | [135] |
58 | GG/ HA | Cartilage regeneration | [35] |
59 | GG/ poloxamer-heparin | Bone marrow stem cells delivery | [65] |
60 | GG/PEG | Retinal pigment epithelial cells regeneration | [37] |
61 | GG/ demineralized bone powder | Bone tissue regeneration | [36] |
62 | GG/Agar | Cartilage regeneration | [39] |
63 | GG/Silk fibroin | Chondrogenic differentiation | [38] |
64 | GG/Saponin | Cartilage regeneration | [40] |
65 | GG/Chondroitin sulfate | Cartilage regeneration | [41] |
66 | GG/ Gelatin | Cartilage regeneration | [136] |
67 | GG/Hesperidin | Cartilage regeneration | [83] |
68 | GG/ duck feet derived collagen | Tissue Engineering | [137] |
69 | GG hydrogel | Intervertebral disc | [106] |
70 | GG/ polyvinyl alcohol | Skin tissue regeneration | [86] |
71 | GG/PVA/Water | Skin tissue regeneration | [138] |
72 | GG/Chitosan/ resveratrol | Gastrointestinal delivery | [87] |
73 | GG/apigenin | Oral drug delivery | [113] |
74 | GG/Laponite Beads | Gastrointestinal drug release | [112] |
75 | Maleate GG/Sericin-chitosan | Mycobacterium tuberculosis | [88] |
76 | GG/sodium alginate/low-methoxyl pectin coated carboxymethyl pullulan-ZnO nanocomposites encapsulating erlotinib | Lung cancer therapy | [139] |
77 | GG/Triamcinolone acetonide | Topical Ocular Delivery | [140] |
78 | GG/Sericin/rice bran albumin | Cancer drug delivery | [141] |
79 | GG/natamycin bilosomes | Ocular pharmacotherapy | [142] |
80 | GG/Methotrexate | Drug delivery | [143] |
81 | GG/brinzolamide | Ocular delivery | [144] |
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Muthukumar, T.; Song, J.E.; Khang, G. Biological Role of Gellan Gum in Improving Scaffold Drug Delivery, Cell Adhesion Properties for Tissue Engineering Applications. Molecules 2019, 24, 4514. https://doi.org/10.3390/molecules24244514
Muthukumar T, Song JE, Khang G. Biological Role of Gellan Gum in Improving Scaffold Drug Delivery, Cell Adhesion Properties for Tissue Engineering Applications. Molecules. 2019; 24(24):4514. https://doi.org/10.3390/molecules24244514
Chicago/Turabian StyleMuthukumar, Thangavelu, Jeong Eun Song, and Gilson Khang. 2019. "Biological Role of Gellan Gum in Improving Scaffold Drug Delivery, Cell Adhesion Properties for Tissue Engineering Applications" Molecules 24, no. 24: 4514. https://doi.org/10.3390/molecules24244514