Antiviral Innate Immunity
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (29 February 2016) | Viewed by 338
Interests: molecular virology; mosquito-borne RNA virus; viral pathogenicity; viral disease; host-virus interactions; viral diagnosis; vaccine; antiviral compounds
Special Issues, Collections and Topics in MDPI journals
An important obstacle that an invading mosquito-borne RNA virus belonging to flavivirus (e.g, dengue, West Nile, yellow fever, Japanese encephalitis, Zika), alphaviruses (e.g., Chikungunya, Ross River, Sindbis, Semliki Forest), or bunyavirus (e.g., Rift Valley fever) genus has to overcome is the host antiviral innate immunity. Understanding the mechanisms of antiviral innate immune responses provides new clues for the development of arthopod-borne virus (arbovirus) control strategies. The host immune response to arbovirus is initiated when the pattern recognition receptors recognize highly conserved motifs in viral products. In vertebrate hosts, such interactions lead to activation of transcription factors which stimulate the expression of genes encoding the type-I interferons and, which in turn, activate the expression of interferon-stimulated genes (ISGs) capable of major antiviral properties. In mosquito vector, RNAi associated to JAK/STAT pathway has been proposed as the most important mechanism of antiviral immune response. In the last years, knowledge on antiviral innate immunity to mosquito-borne RNA virus infection has greatly increased. Recent studies have also shown that arboviruses have developed sophisticated strategies to evade host innate immune responses.
This special issue of Vaccines will cover all the aforementioned topics relevant to antiviral innate immunity against mosquito-borne RNA viruses and their perturbation in both invertebrate vector and vertebrate hosts.
Prof. Dr. Philippe Desprès
Prof. Dr. Philippe Gasque
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Arthropod-borne virus
- RNA virus
- mosquito-borne virus
- vertebrate host
- mosquito vector
- innate immunity
- antiviral immune responses
- pathogen recognition receptors
- type-I interferon pathway
- interferon-stimulated genes
- insect RNAi
- insect JAK/STAT pathway
- viral subversion to innate immune response