Special Issue "Innate and Adaptive Immune Response against Human Herpesviruses"

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Innate and Adaptive Immunity in Vaccination".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 91

Special Issue Editors

Fox Chase Cancer Center, Philadelphia, PA, USA
Interests: cell death pathway; immune response; immunotherapy; molecular targeted therapy
Dr. Ting Zhang
E-Mail Website
Guest Editor
Laboratory of Liver Transplantation, West China Hospital, Sichuan University, Chengdu, China
Interests: programmed cell death; innate immune response; tumor immunology; immunopathology

Special Issue Information

Dear Colleagues,

Human herpesviruses (HHVs) represent a prominent family of enveloped double-stranded DNA viruses, which belong to the Herpesviridae family and are classified into three subfamilies: alpha, beta and gamma herpesviruses. HHVs are widely investigated as they mainly cause cutaneous disease and multiple pathologic abnormalities, and even have oncogenic properties. HHVs are known for their remarkable capacity to establish lifelong latent infections in human hosts, evading host immune surveillance through sophisticated mechanisms. The replication cycle of HHVs involves a meticulously orchestrated series of events, including attachment, entry, nuclear translocation, viral genome replication, gene expression, assembly and egress. These processes are regulated by several viral proteins and interactions with host cellular machinery. The immune system employs both innate and adaptive immunity as fundamental defense mechanisms against infections. Innate immune cells utilize pattern recognition receptors (PRRs) to initiate an inflammatory response. On the other hand, adaptive immunity relies on the recognition of antigens by B and T cells, leading to the generation of specific immune responses. Among these responses, effector cells such as T helper cells and cytotoxic T lymphocytes play pivotal roles in effectively combating infections.

To enhance our understanding of immune system processes, ongoing research is necessary, focusing on several key areas: firstly, investigating the mechanisms by which HHVs trigger host programmed cell death, in turn being eliminated by the host immune response, and how HHVs counteract host innate immunity to evade inducing cell death, representing a crucial area of research; secondly, delving into the role of host immunity in the mechanisms underlying virus latency and reactivation, which holds the potential for providing valuable clinical insights into preventing and treating reinfections, particularly in immunocompromised populations; and lastly, engineering immune cells to mount potent responses against infections holds great promise and merits dedicated investigation. By conducting specialized research in these areas, we can bolster immune responses and develop more effective strategies to combat HHVs. To achieve these purposes, we cordially invite contributions of original articles or reviews.

Dr. Chaoran Yin
Dr. Ting Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • innate immune response
  • adaptive immune response
  • herpesvirus
  • cellular immune response
  • humoral immune response
  • inflammatory response
  • pathogen
  • virus

Published Papers

This special issue is now open for submission.
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