Comprehending Molecular Targets: Mechanisms and Actions in Drug Development

Dear Colleagues,

The identification and validation of drug targets both play a pivotal role in drug discovery and development. Targeted therapies have revolutionized modern medicine by providing more effective and precise treatments for various diseases. Understanding of the molecular mechanisms underlying disease pathogenesis and the interactions between drugs and their targets is crucial for the development of novel therapeutics.

In this Special Issue, we aim to explore the diverse landscape of drug targets across different therapeutic areas. We invite researchers, scientists, and clinicians to contribute original research articles, reviews, and perspectives that will advance our understanding of drugs’ targets. Topics of interest include but are not limited to:

• Molecular mechanisms of drug action
• Identification and validation of novel drug targets
• Targeted therapies for cancer and other diseases
• Target-based drug design and development
• Emerging targets for precision medicine
• Target engagement and pharmacodynamics
• Biomarkers of target engagement and drug response
• Target-based screening and drug discovery strategies
• Personalized medicine approaches targeting specific molecular pathways
• Challenges and opportunities in targeting complex diseases
  

We encourage submissions that encompass interdisciplinary approaches, ranging from basic science to clinical applications. By bringing together cutting-edge research in this field, we aim to foster collaboration and accelerate the translation of scientific discoveries into innovative therapies that improve patient outcomes.

We welcome submissions of original research articles, reviews, and perspectives for inclusion in this Special Issue on "Comprehending Molecular Targets: Mechanisms and Actions in Drug Development".

Dr. Cristina Manuela Drăgoi
Dr. Ion-Bogdan Bogdan Dumitrescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Targets is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• drug development
• therapeutic targets
• drug research
• drug design
• drug–drug interactions
• biochemistry of drug uptake, action, and metabolism
• drug target discovery
• individualized therapy
• pharmacogenomics
• novel therapeutics
• chronobiology
• medicinal chemistry
• biologics
• personalized medicine
• biomolecular targets
• drugs mechanisms of action
• pharmacodynamics
• molecular pathways
• pharmacokinetics
• signal transduction pathways
• receptor biology
• molecular interactions
• drug metabolism
• structural biology
• pharmacotherapeutics
• molecular pharmacology
• target identification
• precision medicine