Insights into Vitamin E Therapy

Dear Colleagues,

In 2022, scientists around the world celebrated the centennial anniversary of the discovery of the essentiality of vitamin E. Since then, many studies highlighted the importance of vitamin E for the maintenance of health and prevention of diseases—facts that received a great deal of attention from scientists and the public.

Scientific research on vitamin E is still an exciting and important issue. Although it has long been known as an antioxidant and radical scavenger, vitamin E is also proposed to act via non-antioxidant modes which include the regulation of gene expression, modulation of gene activity at the posttranslational level, as well as inhibition of cell proliferation, platelet aggregation, monocyte adhesion and several more. Next, metabolites of vitamin E have also been proposed to be bioactive regulatory molecules that may mediate the function of vitamin E in part. The elucidation of the molecular mechanisms and the physiological significance of these non-antioxidant functions of vitamin E and its metabolites is the subject of current and future research.

This Special Issue of Pharmaceuticals on “Insights into Vitamin E Therapy” will display our current knowledge on the use of vitamin E for both maintaining health and preventing diseases by including articles on both experimental and clinical studies as well as reviews focused on the most recent advances in research on the function of vitamin E and its derivatives in medicine. The major focus will be on vitamin E and its effects on different diseases, including studies concerning their pathophysiological and molecular mechanisms. Special attention will be also paid to the synthesis of vitamin E, vitamin derivatives and metabolites, as well as their analytics.

With the aim of providing a dedicated forum open to all scientists engaged in this interdisciplinary field of research, we particularly welcome contributions dealing with the following topics:

• Beneficial effects of vitamin E and its derivates as therapeutics for the maintenance of health and prevention of diseases;
• Synthesis and analysis of vitamin E forms, their derivatives and metabolites, and of vitamin-related compounds;
• Formulations of vitamin E and its derivatives for different medical applications;
• Experimental studies and clinical trials with vitamin E and its derivatives for the treatment of different disorders;
• Recommended dietary intake and allowance, overdosage and safety of vitamin E;
• Molecular modes of action of the different vitamin E forms, their derivatives and metabolites, and of vitamin-related compounds;
• Historical views on clinical trials with vitamin E and its derivatives;
• Future perspectives of vitamin E research;
• Genetic factors associated with the response to vitamin E.

We are looking forward to receiving numerous articles on these and related topics.

Prof. Dr. Stefan Lorkowski
Dr. Maria Wallert
Guest Editors

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• vitamin E synthesis
• non-communicable diseases
• cardiovascular diseases
• cardiometabolic diseases
• fatty liver diseases
• skin diseases
• inflammation
• AVED