Bioactive Compounds through Structural Modification of Natural Products

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 140

Special Issue Editor

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Guest Editor
Laboratory of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Interests: pharmacology of pain; inflammation; cancer; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmacological activity and druggability are two essential factors for drug innovation. The pharmacological activity is indispensable, and the druggability is determined by the physico-chemical, biochemical, pharmacokinetic and safety properties of drugs. Natural products are a rich source of therapeutic drugs. They are unusually featured by structural diversity. The structural modification of natural products should result in a synthesis process ready for industrialization, protect the environment and resources, realize chemical modifications according to the molecular size and complexity of natural products, acquire novel structures through structure–activity relationship analysis, pharmacophore definition, and scaffold hopping. The strategy for structural modification is to increase potency and selectivity, improve physico-chemical, biochemical and pharmacokinetic properties, eliminate or reduce side effects, and attain intellectual properties. This Special Issue will focus on papers showing data with new molecules obtained after molecular modifications in natural products, on the synthesis and/or biological effects of new compounds designed using medicinal chemistry approaches looking to improve the activities of original molecules obtained from natural products against worldwide diseases, including, but not limited to, neglected diseases, chronic inflammatory diseases, cancer, tropical diseases (malaria, leishmaniosis, dengue, zika), neurological diseases, cancer, and COVID-19.

Dr. Patricia Dias Fernandes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • COVID-19
  • inflammation
  • inflammatory bowel diseases
  • endometriosis
  • antinociceptive compounds
  • pulmonary inflammation

Published Papers

This special issue is now open for submission.
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