Please note that, as of 27 April 2018, this Special Issue has been converted into a Topical Collection and is now published here.

Special Issue "Advances in Genome Engineering"

A special issue of Methods and Protocols (ISSN 2409-9279).

Deadline for manuscript submissions: closed (31 May 2018)

Special Issue Editor

Evotec International GmbH, Marie-Curie-Straße 7, D-37079 Göttingen, Germany
Interests: mouse models; recombineering technology; CRISPR/Cas9 technology; Cas9-screens; dCas9-imaging; general regulation of transcription and epigenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

With the emergence of the CRISPR/Cas9 genome-engineering platform an unprecedented variety of novel approaches and possibilities in the generation of cellular model systems has been made available, and many new exciting developments are unveiled on a regular basis.

The current Special Issue aims to provide a forum to (i) discuss the latest technical developments in the fields of general genome engineering technologies, (ii) focus on the establishment of cell-based model systems and on the development of animal models by CRISPR/Cas9 (or similar genome engineering tools), and (iii) give an overview about the current state of art of technology development and novel approaches using genome engineering technologies.

Due to the rapid development of the field this Special Issue invariably will not be able to cover all aspects. However, we aim to give a deep technical insight into the most recent evolution, latest trends and refinements in genomic engineering that is available today.

Dr. Philip Hublitz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Methods and Protocols is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • CRISPR/Cas9

  • HDR/NHEJ Pathways

  • Base Editors


  • Arrayed and Pooled sgRNA-Screening

  • Cas9 Efficiency and Fidelity

  • CRISPR/Cas9 Targeting Strategies

  • Model Generation

Published Papers

There is no accepted submissions to this special issue at this moment.
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