Kinases in Signal Transduction
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (1 May 2021) | Viewed by 294
Special Issue Editor
Interests: biological Mass Spectrometry; proteomics; phosphoproteomics; targeted proteomics; metaproteomics; microbial proteomics; cancer biology; kinases; signal transduction; PTMs; neurological disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The kinases are a small yet diverse family of proteins that regulate most of the signal transduction pathways in a cell. In turn, post-translational modifications such as phosphorylation and ubiquitination regulate kinase activity by altering their structure, their sub-cellular localization, or their interactions with other proteins. Mutations in kinases are the known drivers for several human malignancies, and therefore many FDA-approved targeted therapies are directed towards kinases. However, as kinases exhibit a high degree of structural similarity, their inhibitors are notoriously promiscuous, and researchers are striving to develop potent kinase inhibitors with high specificity. Understanding how the kinases recognize their substrates is another interesting field of research that is driven by developments in phosphoproteomics, chemical proteomics, kinome profiling, array-based technologies, and bioinformatics.
With this Special Issue, the aim is to highlight the cutting-edge research shaping our understanding of kinases and their role in signaling pathways. The present Special Issue welcomes studies ranging from the global profiling of kinases using different analytical methods and omics approaches to studies shedding light onto the role played by individual kinases using traditional molecular and cell biology methods. This is also a call to researchers who are using computational chemistry and bioinformatics to understand kinase sequences and structures, substrate recognition by kinases, and developing small-molecule kinase inhibitors.
Dr. Ritin Sharma
Guest Editor
Manuscript Submission Information
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Keywords
- Kinases
- kinase-substrate analysis
- cell signaling
- kinome profiling
- computer-aided drug design
- kinase inhibitors
- activity-based kinase profiling
- post-translational modifications
- proteomics
- phosphoproteomics
