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Complement Inhibitors: Development, Mechanisms, and Disease Models

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 213

Special Issue Editor

Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
Interests: surface plasmon resonance; X-ray crystallography; the complement system; complement evasion; complement therapeutics; Lyme disease; protein structure–function

Special Issue Information

Dear colleagues,

The complement system is a proteolytic cascade involving dozens of proteins that interact and function with one another to form a first line of defense against invading pathogens. While its role as a primary effector arm of innate immunity is well established, the complement system is also central to diverse physiological processes, including homeostatic maintenance, priming of adaptive immune responses, and clearance of immune complexes. However, when the finely tuned regulation of the complement cascade is lost, the complement system can inappropriately target healthy host tissues. Due to this, the complement system has been implicated in a wide range of human autoimmune and inflammatory diseases. Advances in the understanding of the role of the complement system in different diseases have closely followed improved disease models, major genome-wide association studies, and an increased understanding of the genetic factors contributing to individual complement-related diseases. This knowledge has spurred an increased interest in the field of complement-directed therapeutics. However, it is unlikely that a one-size-fits-all approach will be successful, as the optimal intervention point within the cascade may vary in a disease-specific manner. In this Special Issue on “Complement Inhibitors: Development, Mechanisms, and Disease Models”, we aim to provide an open forum for researchers in the complement field to share new findings on the development and use of complement inhibitors. This Special Issue will cover research on the development of novel synthetic complement inhibitors, structure–function investigations on naturally occurring complement inhibitors and regulators, and research utilizing complement inhibitors to study the roles of specific complement targets in different complement-related pathologies. We welcome original research articles and a limited number of review manuscripts.

Dr. Brandon L. Garcia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Complement inhibitors
  • Complement-directed therapeutics
  • The complement system
  • Structure-based inhibitor design
  • Structure–activity relationships
  • X-ray crystallography
  • Surface plasmon resonance
  • NMR
  • Drug discovery

Published Papers

There is no accepted submissions to this special issue at this moment.
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