Ligands and Conformational Changes in Receptors
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 342
Special Issue Editor
Interests: GPCR; ion channels; molecular dynamics simulations; structure based drug design; taste receptors
Special Issue Information
Dear Colleagues,
The past decade has seen significant advancements in the field of structural biology, particularly in the study of protein receptors, such as, G protein coupled receptors (GPCRs). The use of crystallography and cryo-electron microscopy has allowed us to determine atomic resolution three-dimensional structures, which has revolutionized our understanding of the function properties of these proteins. Additionally, advancements in computing power have enabled researchers to study the activation of protein receptors by their corresponding ligands, a critical step in their functional roles.
This special issue invites colleagues who are interested in protein receptor function studies regulated by ligands using experimental or computational approaches to contribute original research or review articles. The topics of interest include, but are not limited to, receptor-ligand complex structure determination using NMR, crystallography, and cryo-electron microscopy, molecular dynamics simulations on receptor activation by ligands, exploring dynamic interactions between receptors and ligands, receptor structure-based drug discovery, and computational and experimental studies on ligand-receptor interactions.
We welcome contributions that utilize innovative approaches to shed light on the mechanisms involved in activating protein receptors by their corresponding ligands, with the ultimate goal of contributing to the development of novel therapeutic interventions.
Dr. Meng Cui
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- receptor-ligand interactions
- protein dynamics
- structure-based drug discovery
- molecular dynamics simulations
- GPCRs
- molecular basis of receptor activation
