Hallmarks and Biological Targets to Investigate Natural and Synthetic Compounds as Anticancer Drugs
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 295
Special Issue Editors
Interests: chemical modification of natural compounds; medicinal chemistry; food chemistry; antioxidants; antimicrobials
Special Issues, Collections and Topics in MDPI journals
Interests: metalloenzymes; carbonic anhydrase; medicinal chemistry; selenium; organochalcogenide comounds
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The hallmarks of cancer encompass biological and enabling capabilities acquired during tumor development, offering insights into the multifaceted nature of neoplastic diseases and their interactions within the tumor microenvironment. Their recognition could expand the therapeutic arsenal in our hands and improve cancer patient outcomes. The in-depth knowledge of these hallmarks and their related pathways/targets would offer to medicinal chemists new underexplored opportunities in avoiding the rise of resistance mechanisms and improving early detection, screening, treatment, and quality of life for cancer patients. This translational approach must also be driven by the correct evaluation of the neoplastic role of a biological target depending on the genetic/metabolic context, immunity system and efficiency, age, and inflammation.
This Special Issue is devoted to drug discovery efforts focusing on new compounds able to counteract or modulate enzymes, protein, efflux pumps and pathways related to the hallmarks of cancer. Old compounds repurposed for this aim or chemical entities used as probes to open up new scenarios in this field will be of interest for the scientific community.
Research and review articles dealing with this topic and providing experiments in vitro and/or in vivo will be considered. In silico approaches must be confirmed using experimental data. The biological activity of complex natural extracts without a proper chemical characterization or the evaluation of the most representative active compounds will not be considered.
Dr. Simone Carradori
Dr. Andrea Angeli
Guest Editors
Manuscript Submission Information
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Keywords
- natural compounds
- drug repurposing
- synthesis
- cancer
- chemosensitizer
- angiogenesis
- apoptosis
- hallmarks
- inflammation
- pathways
- chemical probes
