Recent Advances in (Phospho)lipid-Based Drug Delivery Nanosystems
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 167
Special Issue Editor
Interests: liposomes; deformable liposomes; propylene glycol liposomes; pH-sensitive liposomes; liposomal hydrogels; vesicular phospholipid gel; (trans)dermal drug delivery; vaginal drug delivery
Special Issue Information
Dear Colleagues,
Nanotechnology plays an important role in improving drug delivery and therapeutic efficacy, offering targeted, localized, controlled and/or prolonged delivery of encapsulated drugs to the desired sites of action in the body while reducing unwanted side-effects and toxicity. Among the various drug nanoformulations that are clinically available, (phospho)lipid-based nanosystems are of particular importance due to their versatility and unique properties. They are biodegradable, biocompatible, and non-toxic and enable the incorporation of different drugs (active compounds, herbal substances, enzymes) varying in lipophilicity and size. (Phospho)lipid-based nanosystems include different types of liposomes that differ in size, morphology, design and surface properties, solid lipid nanoparticles, nanostructured lipid carriers, niosomes, nanoemulsions, and microemulsions. The physicochemical properties of (phospho)lipid-based nanosystems are determined by their composition and drug release profile, the stability of the nanosystem during storage, drug permeation through biological barriers/membranes and interactions with the cells, thus affecting drug bioavailability and therapeutic efficacy. Clinical applications of (phospho)lipid-based drug delivery nanosystems include a variety of nanoformulations for the treatment of infectious diseases, cancer, vaccination, inflammation and pain relief, and are applied by various routes of drug administration.
This Special Issue aims to present recent advances in (phospho)lipid-based drug delivery nanosystems and addresses their design, development, characterization, quality, safety, pharmacodynamic and pharmacokinetic properties.
Prof. Dr. Željka Vanić
Guest Editor
Manuscript Submission Information
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Keywords
- liposomes
- solid lipid nanoparticles
- nanostructured lipid carriers
- nanoemulsions
- niosomes
- controlled drug delivery
- targeted drug delivery
- topical drug delivery
- parenteral drug delivery
