Electrochemical Aptasensors in Clinical Diagnosis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 305
Special Issue Editors
Interests: aptamers; aptasensors; cancer; electrochemistry; clinical diagnosis; SELEX
Interests: biosensors and bioassays; electroanalytical methods of detection in food; environmental and clinical analysis; aptamer selection; aptasensors; genosensors; DNA amplification schemes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The early detection of cancer and other diseases can only be achieved through the quantification of specific biomarkers (proteins, RNA, DNA, cells, etc.) at very low concentrations in biological fluids, the so-called liquid biopsy. This challenge requires new tools with improved selectivity and selectivity. Aptamers, synthetic single-stranded DNA or RNA molecules, meet the requirements of recognition elements and can be selected through an in vitro process called SELEX to bind to biomarker proteins or even certain regions within them. This provides an exciting opportunity to obtain receptors for specific features that make it possible to increase the sensitivity/specificity of the diagnostics. Similar to antibodies but more easily generated, with low production cost, low batch-to-batch variability, reversible folding properties, and low immunogenicity, aptamers are the ideal molecules to be engineered into biosensors (aptasensors), actuators and other devices. Aptasensors offer great potential to detect target proteins, and this field is progressing rapidly towards innovative and promising analytical devices. Electrochemical aptasensors are especially convenient due to their easy miniaturization and integration in microfluidic devices.
In this Special Issue, we seek manuscripts that cover the development of electrochemical aptasensors for their application in clinical diagnosis. The selection of novel aptamers and their characterization is also welcomed.
Dr. Ana Díaz-Fernández
Dr. Noemí de-los-Santos-Álvarez
Guest Editors
Manuscript Submission Information
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Keywords
- aptamers
- electrochemistry
- aptasensors
- biomarkers
- clinical diagnosis
- cancer
- SELEX
- biosensors
