Lung Cancer Diagnostics

Dear Colleagues,

Lung cancer is one of the most common malignant tumors worldwide, and it is the cancer with the highest mortality rate. This outcome occurs even in early stage patients whose tumors have been totally resected. Non-small-cell lung carcinoma is a complex cancer biome composed of malignant cells embedded in a sophisticated tumor microenvironment combined with different initiating cell types, including immune cells, and extracellular matrix proteins. It has been suggested that these patients present signs in their tumor microenvironment that reveal the presence of occult metastasis. The tumor microenvironment contains a series of molecules that interact and form a complex signaling system. Therefore, integrate signals emitted by matricellular proteins, from the mesenchymal–epithelial transition process and the signaling pathway, in surgically resected early-stage non-small-cell lung cancer, may be associated with patients’ clinical outcomes.

Dr. Vera Capelozzi
Guest Editor

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• lung cancer
• microenvironment
• extracellular matrix
• collagen
• metastasis
• prognosis