Confocal Microscopy: Clinical Impacts and Innovation—2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Optical Diagnostics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 67

Special Issue Editor


E-Mail Website
Guest Editor
Department of Neurosurgery, Cologne Medical Center, University Witten, Cologne, Germany
Interests: optic; photonic; confocal microscopy; modern operative techniques; deep machine learning; molecular pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tumor diagnosis and the definition of tumor borders intraoperatively are based on visualization modalities used by surgeons as well as on the histopathologic examination of a limited number of biopsy specimens. Furthermore, optimal surgical therapy is the combination of maximal near-total resection and minimal injury of normal tissues, achieved only if it is possible to identify intraoperative cellular structures and differentiate tumor tissue from normal functional tissue, in order to resect a tumor completely and protect the normal tissue. To achieve this goal, we need new technological equipment combined with new surgical concepts.

The principle of confocal laser endomicroscopy (CLE), based on extreme miniaturization of the microscope imaging head, offers the possibility of in vivo microscopy with subcellular and subnuclear resolution. Clear visualization of the cytoarchitecture can be achieved with a 400-fold to 1000-fold magnification.

In oncological diagnosis and surgery, CLE would allow, on the one hand, intraoperative detection and differentiation of single tumor cells (without the need of fast biopsies) and, on the other hand, the definition of borders between tumors and normal tissue on a cellular level, making surgical resection much more accurate than ever before. The application and implementation of CLE-assisted surgery in surgical oncology increases not only the diagnostic but also the therapeutic options by extending the resection borders of cancer on a cellular level and, more importantly, by protecting the functionality of normal tissues.

For this Special Issue, we welcome studies from authors working on implementing in vivo and ex vivo surgical and clinical concepts and techniques of confocal laser endomicroscopy in their treatments.

Potential topics of interest include but are not limited to the following:

  • Confocal-assisted surgery for oncologic brain and head and neck surgery as well as for other disciplines related to oncological surgery;
  • New frontiers in fluorescence microscopy used for surgical oncology;
  • Advances in intraoperative visualization modalities regarding tumor differentiation;
  • Implementation of cell imaging in different oncologic working disciplines;
  • New concepts of cellular surgical cancer therapies in the operation theatre;
  • Embedded technological systems for tumor margin differentiation and cellular analysis in thoracic, abdominal, and urological diseases;
  • Deep machine learning techniques for confocal microscopy in pathology.

Prof. Dr. Cleopatra Charalampaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • confocal laser endomicroscopy
  • diagnosis
  • biopsy specimens
  • tumor
  • cell imaging
  • deep machine learning techniques

Related Special Issue

Published Papers

This special issue is now open for submission.
Back to TopTop