Epigenetic Regulation in Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 70
Special Issue Editor
Interests: transcription factors; cancer metabolism; epigenetics; RNA methylation; pathogenic variants; DDR; Fanconi anemia signaling; DNA-binding proteins
Special Issue Information
Dear Colleagues,
Epigenetic modifications play a pivotal role in governing oncogenes, tumor suppressor genes, and the tumor microenvironment, offering a promising avenue for cancer therapy due to their heritable and reversible properties. Various epigenetic modifications, encompassing DNA methylation, histone modifications, microRNAs, and nucleosome remodeling, intricately regulate gene expression in cancer. Dysregulation of the epigenome emerges as a significant contributor to aberrant transcriptional programs in cancer, underscoring the interplay between dysregulated genetic and epigenetic mechanisms. The inherent heterogeneity of cancer necessitates precise personalized therapy utilizing epigenetic drugs, facilitated by high-throughput epigenome mapping technologies. The interconnected cancer hallmarks of metabolic rewiring and epigenetic remodeling exert influence on immune escape and immunosurveillance. Understanding the role of epigenetic factors in hormone therapy response is crucial for overcoming therapeutic resistance. Furthermore, the emerging field of epitranscriptomics, involving RNA chemical modifications, introduces RNA-modifying proteins as potential pharmacological targets and diagnostic markers in the realm of cancer research.
Dr. Sudhir Rai
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oncogenes
- tumor suppressor genes
- tumor microenvironment
- cancer therapy
- DNA and histone methylation
- microRNAs
- epitranscriptomics
- RNA modifications
- modifying proteins
