Cell Adhesion in Human Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 58
Special Issue Editors
Interests: tight junctions; p63; pathophysiology; cell biology; molecular pathology; oncology
Special Issues, Collections and Topics in MDPI journals
Interests: vitamin D; tight junctions; pathophysiology; molecular pathology; oncology
Interests: lung cancer; claudin; biological homeostasis; anticancer drug resistance; functional natural compounds; intercellular barrier
Special Issue Information
Dear Colleagues,
Cell-to-cell adhesion is a key element in epithelial tissue integrity and homeostasis. The loss of cell adhesion promotes epithelial to mesenchymal transition (EMT). Cadherin–catenin complexes are integral components of the adherens junctions crucial for cell–cell adhesion. The dysregulation of these complexes is linked to cancer development. Furthermore, tight junctions (TJs) are cell adhesion complexes that exist on the most apical side of the intercellular space between epithelial cells. TJs are composed of membrane proteins such as claudin (CLDN), occludin, and junctional adhesion molecules (JAMs), the tricellular TJ proteins angulin-1/lipolysis-stimulated lipoprotein receptor (LSR) and tricellulin, and scaffold proteins such as zonula occludens. The scaffold proteins including cingulin (CGN) connect with microtubules and actin. TJ proteins play roles beyond permeability barrier functions and control cell proliferation and differentiation. The abnormality of TJ proteins closely contributes to EMT and the malignancy of various cancers. The relation between TJs and the signal transduction pathways affects cancer cell growth, invasion, migration, and metabolism. This Special Issue on “Cell Adhesion in Human Cancer” will comprise a selection of original research papers and reviews focusing on the molecular mechanisms and the pathophysiology of cancer for the development of novel therapeutic and diagnostic approaches.
Prof. Dr. Takashi Kojima
Prof. Dr. Makoto Osanai
Prof. Dr. Akira Ikari
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell-to-cell adhesion
- tight junctions
- cytoskeleton
- cancer
- signal transduction pathways
- transcriptional factors
- EMT
- cell metabolism
- mechanical tension
- human cells
