Genome Instability and Human Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 15 September 2024 | Viewed by 104
Special Issue Editor
Special Issue Information
Dear Colleagues,
Genomic instability is not only a hallmark of cancer but also an enabling characteristic that fuels cancer progression. Genomic instability in cancer cells also contributes to the evolving intra-tumor heterogeneity and the rise of drug-resistant cancer cells after chemotherapy or targeted therapy. However, cancer cells still need to maintain their genomes in a delicate stability to avoid the cellular catastrophe, which could be triggered by excessive instability in the genome. Cancer cells depend on various mechanisms to suppress their genomic instability from reaching a catastrophic point, which constitutes a vulnerability that can be exploited for therapeutic interventions. Targeting cancer-cell-specific dependency on mechanisms that suppress the genomic instability may create a synthetic lethality scenario that could kill cancer cells specifically or boost tumor-targeted immunity by activating an innate immune response, enhancing the intrinsic immunogenicity of cancer cells, or modulating the tumor microenvironment.
Dr. Jian Ouyang
Guest Editor
Manuscript Submission Information
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Keywords
- genomic instability
- cancer progression
- drug resistance
- tumor-targeted immunity
