The Parallel Universe of RNA beyond the Codifying Genome: ncRNAs, RNA Editing, RBP, and Epitranscriptome in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".
Deadline for manuscript submissions: 15 August 2024 | Viewed by 292
Special Issue Editors
Interests: cell differentiation; development; stem cells; transcription factors; epigenetics
Special Issue Information
Dear Colleagues,
The dynamic and adaptable biological and chemical information found in the epigenome/epitranscriptome provides a new perspective for the regulation of gene expression. RNAs play several roles in different biological processes as structural components (rRNAs), translators (tRNAs), conveyors of genetic information (mRNAs), and as regulators (ncRNAs, eRNAs). Increasing evidence indicates that all classes of cellular RNAs are subjected to extensive enzymatic base modifications, including mRNAs that are produced in cells in precisely timed flashing bursts.
The RNA metabolism (such as splicing, processing, exporting, translation, and degradation) and functions are affected by co- or post-transcriptional chemical modifications that ultimately regulate and shape the cellular transcriptome and proteome.
Advances in experimental techniques have facilitated the identification of different epitranscriptomic modifications in both coding and untranslated regions. The dynamic and reversible RNA base modifications (such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), and N1-methyladenosine) are catalyzed by distinct epigenetic players (writers, readers, and erasers), the characterization of which will advance our epitranscriptomic understanding of functional genomics.
We warmly welcome contributions on scientific and technical aspects of RNA biology, presenting new viewpoints, and discussing the potential directions of future research in this field.
Dr. Laura Casalino
Dr. Amelia Cimmino
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- RNA editing
- ncRNA
- RNA binding proteins (RBPs)
- epitranscriptome
- RNA methylation
