Special Issue "Epigenetics and Transcription Networks in Leukemia"

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 125

Special Issue Editor

Department of Cellular & Molecular Physiology, Penn State College of Medicine, Penn State Cancer Institute, 500 University Drive, Hershey, PA 17033, USA
Interests: transcription; epigenetics; chromatin structure; leukemia; stem cells

Special Issue Information

Dear Colleagues,

Leukemias are malignant disorders of the blood and bone marrow. Leukemia is the eleventh most common cancer in the United States. In 2023, it is estimated that there will be about 59,610 new cases of leukemia and 23,710 deaths from leukemia in the US. The diseases are largely understood to occur due to alterations in hematopoietic stem cells that cause their transformation into proliferative leukemia stem cells, initiating and maintaining these diseases. Epigenetic and transcription alterations play substantial roles as key functions of leukemia stem cells, such as self-renewal and resistance to standard therapy.

Epigenetic alterations, mainly DNA hypermethylation, histone modifications/remodeling, and aberrant non-coding RNA expressions, are three main epigenetic variations that have been implicated to play a role in leukemia progression.  Recently, m6A RNA modification has also been shown to alter the epitranscriptome during leukemogenesis. Different epigenetic-based approaches have been developed and tested to inhibit or reverse the abnormal expression of epigenetic factors in leukemia. A better understanding of epigenetic and transcriptional aspects of leukemogenesis will shed light on new diagnostic and therapeutic approaches, thus greatly improving the outcomes of patients with hematological malignancies.

This special Issue will focus on epigenetic findings elucidating the molecular mechanisms of the development, progression and therapeutic resistance of leukemia. Original research or review articles related to oncogenesis, prognosis, new therapeutic approaches and treatment resistance are welcome.

Dr. Yi Qiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • leukemia
  • epigenetics
  • gene regulation
  • genetic mutation
  • chemoresistance
  • therapy

Published Papers

This special issue is now open for submission.
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