Study Designs and Quantitative Tools in Rare and Life-Threatening Brain Tumor
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 20 October 2024 | Viewed by 109
Special Issue Editor
Special Issue Information
Dear Colleagues,
Glioblastoma is a rare, life-threatening, and highly difficult to cure disease. It has shown high failure in phase 3 glioblastoma trials, even though previous phase 2 trials showed promising efficacy. There may be a need for earlier studies to become more reliable and for the use of evidence-based quantitative tools to overcome the disconnection from phase 2 to phase 3 trials. This disconnection could be occurring for several reasons: design restriction of preclinical studies and differences between animals and human, traditional single-arm trials in phase 2 trials in GBM, and the surrogate of progression-free survival of phase 2 trials for overall survival in phase 3 trials. With the recent advancements in technology and programming languages, we are able to utilize these new technologies to develop novel study designs using quantitative tools.
Dr. Wonsuk Yoo
Guest Editor
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Keywords
- brain tumor
- glioblastoma
- clinical trial
