Effects of Radiotherapy on the Tumor Microenvironment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 15 August 2024 | Viewed by 104
Special Issue Editors
Interests: immunotherapy; tumor microenvironment; biomarker
Interests: onco-immunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Whilst the direct DNA damaging effects of radiotherapy are well known, in more recent years it has become apparent that radiotherapy can also have multiple effects on the tumor microenvironment (TME) including recruitment of immune cells. Whilst radiotherapy can induce the recruitment of immune stimulatory cells into the TME, it can also induce immune-suppressive cells, and the balance between these immune cells can dictate whether radiotherapy is able to generate anti-tumor immune responses which can improve patient outcomes.
Some pre-clinical models demonstrate that radiotherapy can prime responses which are dependent on T-cell infiltration into the tumor. However, in other tumor models which are devoid of T-cells and contain high numbers of myeloid cells, radiotherapy appears instead to cause further infiltration of suppressive myeloid cells. Furthermore, instances of abscopal responses are rarely described in the clinic, and trials of radiotherapy and immune checkpoint inhibitors have to date been limited.
This Special Issue will delve deep into how radiotherapy can affect the tumor microenvironment, mechanisms of immune responses to radiotherapy and potential immune biomarkers of radiotherapy response, along with papers which detail how potential biomarkers might be used to determine effective radiotherapy-immunotherapy combinations through mechanistic studies in pre-clinical models.
Dr. Eleanor J. Cheadle
Dr. Jamie Honeychurch
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- radiotherapy
- tumor microenvironment
- immune response
- biomarkers
- stroma
