Microglia in Neurodegeneration 2.0
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 290
Special Issue Editor
Interests: neuron–glia interactions; microglia; brain physiopathology; exosomes; in vitro and in vivo models; epigenetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The role of microglia in brain physiology is becoming increasingly important, and it is now established that changes in their function are crucial in neurodegenerative diseases. Therefore, microglia have become an important target to try and counteract neurodegeneration. Many efforts have been made to identify the cellular, molecular, and epigenetic mechanisms underlying the involvement of microglia in neurodegeneration. In particular, attention has been focused on the phenotypic change of microglia from M2, neuroprotective, to M1, neurotoxic, in an attempt to find new potential therapeutic targets. Furthermore, the communication systems between microglia and other central nervous system cells, especially neurons, have been studied to identify alterations potentially involved in different neuropathological conditions, with the idea that the modulation of this communication through endogenous or exogenous biomolecules may modulate microglial phenotype and neurodegeneration. Therefore, this Special Issue, “Microglia in Neurodegeneration”, aims to collect the most relevant and new research findings in the field from (i) the identification and characterization of endogenous molecules and communication mechanisms involved in neuron–microglia crosstalk in physiopathological conditions, to (ii) the molecular and epigenetic mechanisms involved in microglial shift from the M2 to M1 phenotype, and to (iii) the design and testing of molecules able to modulate neuron–microglia interactions and/or microglial phenotypic shift. With this Special Issue, we intend to collect and disseminate the most recent and innovative findings of this important research field. Furthermore, this is also a good opportunity for scientists of the field to show their recent works, both to other researchers of the field and to a wider audience of readers.
Prof. Dr. Barbara Monti
Guest Editor
Manuscript Submission Information
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Keywords
- neuron–microglia communication systems
- released molecules and exosomes
- microglial phenotypes
- molecular and epigenetic mechanisms
- drug design
