Lymphangiogenesis in Health and Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 10 September 2024 | Viewed by 255
Special Issue Editor
Interests: lymphangiogenesis; lymphatic endothelial cells; lymph nodes; cancer metastasis; inflammatory modulation; secondary lymphedema; wound healing; diabetes; aging; sexual differences
Special Issue Information
Dear Colleagues,
Lymphangiogenesis is closely interlinked with both physiological and pathological conditions, where proliferating lymphatic endothelial cells are involved in forming a lymphatic transport pathway for fluid homeostasis, metabolite clearance, and immune surveillance to regulate tissue-specific functions. The understanding of structural and functional features of organ-specific lymphangiogenesis will provide a basis for elucidating the potential therapeutic avenues for targeting lymphatic-related diseases.
Advances during the past two decades have dramatically increased our knowledge of the mechanisms of lymphangiogenesis, which is regulated by various signaling cascades, including growth factors, cytokines, and chemokines. Some of the cellular mediators also work as a source of lymphangiogenic molecules, e.g., macrophages, mast cells, and other immune cells. In particular, recent findings on lymphangiogenesis driven by VEGF-C/VEGFR-3 signaling and genotoxic stress-induced IL-6 for supporting injured bone regeneration, and the involvement of impaired meningeal lymphatics with the microglial inflammatory response, will broaden our thinking and perspectives about the topic of “Lymphangiogenesis in Health and Disease”.
In this Special Issue, we will explore novel research findings and technical solutions in the field of lymphangiogenesis, and discuss its theoretical basis and practical implications in health (e.g., aging and sexual differences), and diseases (e.g., lymphedema, inflammation, and cancer). Therefore, we look forward to receiving your contributions for experimental and therapeutic approaches to regulate lymphatic remodeling and lymphangiogenesis, as well as efforts to explore the molecular and cellular mechanisms underlying these processes.
Dr. Rui-Cheng Ji
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lymphatic endothelial cells
- lymphatic vessels
- lymphangiogenic molecules
