Membrane Transport Proteins and Chemoresistance
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 795
Special Issue Editor
Interests: membrane proteins; ion channels; TRP channels; CFTR channel; cancer; anticancer drugs; mitochondria; lysosomes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mammalian membrane transport proteins are integral for maintaining cellular homeostasis, extruding harmful xenobiotics, and regulating nutrient uptake. Being at the forefront of signal transduction, these membrane transporters communicate with distinct intracellular compartments and establish specialized microenvironments to facilitate a plethora of biological activities. In malignant states, however, these transporters are often sabotaged in order to drive oncogenesis and to de-regulate cellular survival. Employing precise animal models, advanced imaging techniques, functional genomics, computational pharmacology, and high-throughput screening, we are entering an exciting era of biomedical research and developing in-depth appreciation, through the lens of membrane transporters, for the molecular processes that promote tumor progression, angiogenesis, and metastasis. Despite recent advancements in anticancer therapies, such as oncolytic virus therapy, monoclonal antibody therapy, and gene therapy, cancer relapse still stagnates as a major obstacle to therapeutic progress. Disarming chemoresistance through strategic therapeutic interventions has thus become a shared interest for both scientific researchers and clinicians. Recently, an increasing number of studies have highlighted the potential involvement of membrane transporters in the acquisition of chemoresistance.
The aim of this Special Issue is to integrate current knowledge regarding the benefit of targeting membrane transport proteins in battling chemoresistance. Research papers and review manuscripts depicting a special focus on ion channels and transporters are cordially invited.
Dr. Yassine El Hiani
Guest Editor
Manuscript Submission Information
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Keywords
- membrane transport proteins
- ion channels
- transporters
- cancer
- chemotherapeutics
- chemotherapy
- chemoresistance
