Mitochondrial ROS in Health and Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 69
Special Issue Editor
Interests: proteomics; protein-protein interactions; protein-ligand interactions; oxidative phosphorylation; mitochondria; metabolons; aging research; drug discovery; native electrophoresis; analytical ultracentrifugation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are extremely membrane-rich organelles with a central role in metabolism and key functions in cellular signaling and cell survival as well. Therefore, mitochondria are involved in various diseases and the aging process, which has been providing a major impetus for extensive research on mitochondrial structure and function. In recent decades, many essential physiological roles of (mitochondrial) ROS were (re)established, such as in the immune response, cell cycle, and lifespan control.
Though the detrimental role of free radicals and other reactive species on organisms was the prevailing view for a long time, the health- and lifespan-promoting effects of ROS are an emerging topic with some predominantly forgotten roots, e.g., about the medicinal benefits of hydrogen peroxide dating more than a hundred years back. Similarly, many medicinally powerful biomolecules exert oxidative effects either directly or indirectly, including via mitochondrial ROS generation, e.g., paclitaxel and artemisinin.
This Special Issue focuses on the current advances in mitochondrial-derived ROS and their effects on health and disease involving natural-based biomolecules. Both review manuscripts and original research articles are welcome to convey up-to-date insights and avenues of future research.
Dr. Frank Krause
Guest Editor
Manuscript Submission Information
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Keywords
- aging
- apoptosis
- respiratory chain
- redox signaling
- paclitaxel
