Bacterial Metabolites and Structures in Asthma
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (1 April 2022) | Viewed by 731
Special Issue Editors
Interests: bacterial metabolites and polymers; lipids; analytical chemistry; NMR; MS; asthma; early origins of asthma
Interests: preconceptional and prenatal origins of chronic lung disease; preclinical intervention with bacterial signaling molecules; contribution of small RNAs in establishing disease risks
Special Issue Information
Dear Colleagues,
Asthma is a highly prevalent chronic disease worldwide. Unfortunately, current treatments are limited to the control of symptoms without achieving cure. Recently, it has become clear that the composition and metabolic activities of the host microbiome are essential for maintaining health. In parallel, altered airway microbiome has been described for asthma. This led to the postulate that the microbiome represents a new “target organ” for therapeutic manipulation which opens fundamentally new perspectives for the prevention and/or treatment of asthma.
Bacteria interact with epithelia and the underlying immune cells via binding of their cell envelope structures to cellular pathogen recognition receptors. They further produce metabolites, such as short-chain fatty acids. Metabolites from intestinal bacteria enter the systemic circulation via the portal vein and can therefore act on distant organs such as the lungs. However, there are significant knowledge gaps regarding the characterization of microbial compounds and how they act in detail on epithelia and immune cells of the lung.
This Special Issue, entitled “Bacterial Metabolites and Structures in Asthma”, aims to compile current evidence on how environmental or disease-induced changes in the microbiota affect bacterial surface structures and/or metabolite profiles and how this might again influence asthma worsening or protection.
We would therefore like to invite scientists to submit manuscripts addressing the latest findings and discoveries on microbial molecules related to asthma from the fields of medicine, chemistry, and immunology. Contributions to this Special Issue are solicited in the form of reviews, research articles, and communications.
Dr. Katarzyna Anna Duda
Prof. Dr. Susanne Krauss-Etschmann
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Asthma
- Microbiome
- Bacterial metabolites and structures
- Gut–lung axis
- Structure-function relationship
