Unraveling the Complexity of the Human Spliceosome and RNA Splicing
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Nucleic Acids".
Deadline for manuscript submissions: 30 July 2024 | Viewed by 169
Special Issue Editor
Interests: RNA-seq; alternative splicing; sequence alignment; gene annotation; miRNAs; computational biology; gene annotation; alternative splicing; genomics and transcriptomics
Special Issue Information
Dear Colleagues,
RNA splicing is a fundamental molecular process leading to the formation of functional mRNAs and proteins from a gene encoded in the DNA. Eukaryotic genes are interrupted, with coding DNA separated by intervening stretches of a non-coding sequence. The removal of the non-coding regions from the pre-mRNA transcripts, or splicing, is accomplished via a complex of small nuclear RNAs and proteins, forming the spliceosome. Significant advances have been made in determining the components of the spliceosome, its 3D structure, and how the accurate recognition and selection of splice sites takes place during splicing; however, questions remain, as these areas are under active investigation.
This Special Issue of Biomolecules aims to provide an overview of novel information and current research regarding the characterization of the human spliceosome and pre-mRNA splicing. Contributions in the form of original research papers and reviews that address the following topics are welcome: spliceosome organization, structure, and function; the regulation of RNA splicing; RNA splicing in human physiology and development; and the computational modeling of RNA splicing. However, studies related to the discovery and role of RNA splicing in disease, and technologies able to study RNA splicing and the spliceosome, are generally considered outside the scope of the Biomolecules journal.
Our aim is to provide a forum for investigators from around the globe to create a compendium of research efforts and advances in this fundamental area of molecular biology.
Dr. Liliana Florea
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- spliceosome
- splicing regulation
- RNA splicing in human physiology and development
- computational modelling
