Exploring the Dynamics of Protein Lysine Methylation and Its Implication in Disease

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".

Deadline for manuscript submissions: 1 June 2024 | Viewed by 117

Special Issue Editor

E-Mail Website
Guest Editor
Institute of Biochemistry, Carleton University, Ottawa, ON, Canada
Interests: the discovery and characterization of how proteins coordinate and work; functional proteomics; how proteins dynamically interact with each other; how PTM-modifying enzymes select substrates; changes in protein signaling or regulatory networks that accompany disease progression or resistance to treatment

Special Issue Information

Dear Colleagues,

This Special Issue delves into the dynamic world of protein lysine methylation within the realm of functional proteomics, aiming to illuminate its crucial roles in both normal biology and disease progression. Lysine methylation, a pivotal post-translational modification, orchestrates a multitude of cellular functions by regulating protein–protein interactions, enzymatic activities, and signaling pathways. This compilation of articles endeavors to unravel the complexities of lysine methylation, exploring its impact on protein dynamics, enzymatic substrate selection, and alterations in regulatory networks associated with various diseases.

From the nuanced understanding of lysine methylation's role in protein coordination to its implications in disease pathogenesis and therapy resistance, this issue showcases cutting-edge research from international researchers. The insights gained from these studies promise to advance our understanding of basic biology regulated by protein lysine methylation and its impact on disease mechanisms, paving the way for innovative interventions targeting protein lysine methylation in diverse pathological conditions.

Dr. Kyle K. Biggar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • protein regulation
  • disease mechanisms
  • biomarkers and therapeutic targets
  • cellular signaling
  • mass spectrometry

Published Papers

This special issue is now open for submission.
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