Novel Insights into β-Arrestins and G Protein-Coupled Receptor Signaling
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 255
Special Issue Editors
2. MTA-SE Laboratory of Molecular Physiology, Hungarian Academy of Sciences and Semmelweis University, 1085 Budapest, Hungary
Interests: angiotensin receptor; G-protein; receptor internalization; arrestin; bias agonism
2. MTA-SE Laboratory of Molecular Physiology, Hungarian Academy of Sciences and Semmelweis University, 1085 Budapest, Hungary
Interests: molecular pharmacology; G-protein coupled receptor; cell pharmacology
Special Issue Information
Dear Colleagues,
G protein-coupled receptors (GPCRs) are one of the most widely used targets in therapy due to their important regulatory functions and specific ligand binding sites, which make them suitable for drug targeting. GPCRs exert their biological functions via G protein-dependent and independent signaling. Recent advances in the structural biology of GPCRs and their interacting proteins opened new opportunities to design new drugs with improved specificity and affinity. β-arrestin proteins bind to activated and phosphorylated receptors and play key roles in desensitization, trafficking, and G protein-independent signaling of GPCRs. β-arrestin-regulated signaling mechanisms are involved in multiple cellular processes, including scaffolding, regulation of G protein signaling, transcription, cell growth and survival, cytoskeletal rearrangement, and cell migration. Although most β-arrestin functions are related to GPCRs, they are apparently more diverse, since several reports suggest that they can also act independently of GPCRs. Furthermore, β-arrestin-dependent processes play roles in pathophysiological conditions in a number of disease models, as well, which led to the exploration of specific targeting of these pathways during the last two decades.
The focus of this Special Issue, entitled “Novel Insights into Beta-Arrestins and G Protein-Coupled Receptor Signaling”, will focus on recent developments in the field of GPCRs and β-arrestins and their signaling functions. We seek both original papers and reviews focusing on the novel aspects of these topics.
Prof. Dr. László Hunyady
Dr. Gábor Turu
Guest Editors
Manuscript Submission Information
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Keywords
- β-arrestin
- G protein-coupled receptor
- structure and function of GPCRs
- receptor phosphorylation
- cellular signaling
- receptor pharmacology
