The Role of Metals Ions in Neurodegenerative Diseases
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 15 August 2024 | Viewed by 172
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neurological disorders represent one of the major risks for the normal life of human society, especially among elderly people. Alzheimer’s disease and Parkinson’s disease are the most common and best studied forms of these disorders but a series of less frequent but very serious diseases (like Huntington’s disease, Wilson’s disease, ALS, PSP, etc.) belong also to this category. There are some common features of neurological disorders. Among them, abnormal conformational changes and/or the subsequent aggregation of specific proteins are the best known, but the involvement of various metal ions (mainly copper, iron, and zinc) in these processes is also widely suggested. A huge number of previous publications demonstrated the role of metal ion accumulation in the development of neurological disorders, either via direct complex formation or through the oxidative damage/cleavage of specific peptides or proteins. Unfortunately, effective therapy does not exist for the treatment or prevention of these diseases. Therefore, further studies are required on all aspects of the metal ion peptide–protein interaction and the results may significantly contribute to a better understanding of the development of neurological disorders.
In this Special Issue, manuscripts describing the molecular background of metal ion peptide–protein interactions are collected with a special emphasis on the copper, zinc, and iron complexes of the amyloid beta and peptide fragments of prion and Tau proteins. The results of biological and/or clinical studies are also invited. It is widely accepted that chelation therapy can be used for the treatment of certain forms of neurodegeneration and the submission of manuscripts related to this subject is also encouraged.
Prof. Dr. Imre Sòvágó
Guest Editor
Manuscript Submission Information
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Keywords
- Alzheimer’s disease
- Parkinson’s disease
- metal complexes
- amyloid-beta
- peptide fragments of prion and tau proteins
