Recent Advances in Adduct Science
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 31 August 2024 | Viewed by 52
Special Issue Editors
Interests: DNA adductomics; environmental carcinogenesis; mutational signatures; cancer prevention
Special Issue Information
Dear Colleagues,
Humans are exposed to an extremely large number of chemical substances in their daily lives. When these chemicals are taken into the body, they can be generally detoxified by drug-metabolizing enzymes, and usually excreted. Some of these chemicals however, can bind to proteins, nucleic acids, and other macromolecules in the body directly or after metabolic activation, to form adducts (addition + product). Some of these adducts have been widely used in epidemiological and mechanistic studies as biomarkers to elucidate the relationship between chemical substances and diseases.
Additionally, the biological effects of these adducts are known to be involved in the pathogenesis of various diseases, including cancer, through intracellular signal transduction, changes in gene expression, and the introduction of genomic mutations. Recently, with the development of innovative analytical techniques, not only an increasing number of protein- or nucleic acid-adducts have been discovered, but also their biological effects have been unveiled. Furthermore, these findings are expected to be applied to elucidate the precise mechanisms of disease development, to specify the etiology of diseases, to develop preventive strategies based on risk assessment, and eventually to lead to drug discovery.
The International Adductomics Consortium (IAC) was established 2023 with the aim of further developing the many possibilities of adduct science. The members of this consortium are researchers from various backgrounds who are interested in the biology of adducts, and the consortium aims to establish a platform to support this research by developing adduct databases and sharing resources and analytical methods with the scientific community. To mark the inauguration of the IAC, we would like to take this opportunity to organize a special issue, entitled Recent Advances in Adduct Science, as a forum to provide the latest information on adduct science research.
Dr. Yukari Totsuka
Dr. Haruhiko Sugimura
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- adductomics
- protein- or nucleic acid-adducts
- biomarkers
- exposome
- genomic mutations
- disease etiology
- preventive strategies
- drug discovery
- risk assessment
