Filtering Bleb Characteristics in Combined Cataract Surgery with Ex-PRESS Implant vs. Non-Penetrating Deep Sclerectomy. A Prospective, Randomized, Multi-Center Study
, Marcos Muñoz 1,*,†, Marta Castany 2, Alfonso Gil 3, Alberto Martinez 3, Francisco Muñoz-Negrete 4, Jose Urcelay 5 and Javier Moreno-Montañes 6Round 1
Reviewer 1 Report
The authors evaluated the difference of bleb appearance between Ex-PRESS implantation and NPTS procedure in a multicenter, randomized study. The manuscript is well-written and well-organized. I just have some minor concerns:
1. In ‘Abstract’, the differences between the two groups should be highlighted in the section ‘Results’ and ‘Conclusion’.
2. Line 88, do the authors mean ‘myopia ≦-6 diopters’?
Author Response
Please see the attachment
Author Response File: 
Author Response.pdf
Reviewer 2 Report
Dear authors,
you presented an interesting research regarding bleb morphology after two different glaucoma procedures. This is a well-written article which could be considered for publication. In my opinion, both the results and discussion section should be briefly implemented: in particular, have you found any correlation between the rate of post-operative slit-lamp interventions in the ExPRESS group and the morphology or vascularization of the bleb? Since a significative rate of re-interventions have been reported, this element could have affected the vascularization and the area of the bleb.
Moreover, the use of a subjective grading system remains a strong limitation of this study, since OCT analysis could have highlighted much more characteristic and morphological evolution of the blebs.
Finally, some small correction should be perfomed:
1. Line 97: please adjust the fractions.
2. Lines 164-174: please consider switching the position of Table 3 and 4, since Table 4 seems to be the report of general findings in the two groups.
3. Line 247: is it month 1 or month 12? Please correct.
4. Lines 278-299: since no statistical analysis was performed regarding the use of 5FU instead of other anti-fibrogenic agents, this sections coul be summarized.
5. Lines 322-324: AS-OCT has been used in a recent paper to compare the morphology of some MIGS-plus procedures. Please, consider adding the reference. https://pubmed.ncbi.nlm.nih.gov/35626405/
6. Please, perform a review of the language since some typos are still present.
Kind regards
Author Response
Please see the attachment
Author Response File: Author Response.pdf
