Biological and Pharmacological Properties of Carbon Monoxide: A General Overview

Round 1

Reviewer 1 Report

This is a very interesting and comprehensive review. I have a few comments:

1. the paper reads well but should benefit from a moderate lingustic revision and shortening of some 15%
2. For search of accuracy these papers hsould be quoted and discussed in the setting of immunoinflammatory and autoimmune diseases benefiting from CORM treatment

 

Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation. Chora AA, Fontoura P, Cunha A, Pais TF, Cardoso S, Ho PP, Lee LY, Sobel RA, Steinman L, Soares MP.J Clin Invest. 2007 Feb;117(2):438-47       Carbon monoxide-releasing molecule-A1 (CORM-A1) improves clinical signs of experimental autoimmune uveoretinitis (EAU) in rats. Fagone P, Mangano K, Mammana S, Cavalli E, Di Marco R, Barcellona ML, Salvatorelli L, Magro G, Nicoletti F.Clin Immunol. 2015 Apr;157(2):198-204   Pharmacological application of carbon monoxide ameliorates islet-directed autoimmunity in mice via anti-inflammatory and anti-apoptotic effects. Nikolic I, Saksida T, Mangano K, Vujicic M, Stojanovic I, Nicoletti F, Stosic-Grujicic S.Diabetologia. 2014 May;57(5):980-90   Carbon monoxide-releasing molecule-A1 (CORM-A1) improves clinical signs of experimental autoimmune uveoretinitis (EAU) in rats. Fagone P, Mangano K, Mammana S, Cavalli E, Di Marco R, Barcellona ML, Salvatorelli L, Magro G, Nicoletti F. Clin Immunol. 2015 Apr;157(2):198-204

Author Response

Reply to Reviewer 1

 

     We are grateful to the Reviewer for valuable comments and thorough review of our  paper.

Please, find my replies below.

 

1. The paper reads well but should benefit from a moderate lingustic revision and shortening of some 15%

Taking into account comment of the Reviewer suggesting that English needs improvement we want to inform you that that our paper was checked for proper English usage by a professional Polish-English translator.

 

We tried to shorten the article as suggested by the Reviewer. However, due to comments from Reviewer 2, we were unable to do so because the Reviewer 2 suggested extending the sections on the role of CO in cancer, in the metabolic process and in the central nervous system. Furthermore, Reviewer 2 suggested adding figures to emphasize the important parts of our paper.

1. For search of accuracy these papers hsould be quoted and discussed in the setting of immunoinflammatory and autoimmune diseases benefiting from CORM treatment.

The publications suggested by the Reviewer have been cited and discussed.

Author Response File: Author Response.docx

Reviewer 2 Report

This is a review that attempts to describe the pharmacological properties of CO and its potential as a therapeutic agent. However, there is not much actual discussion regarding CO particularly in the section "CO in the central nervous system".

The section of CO in cancer cells is just a summary of a few different papers without any real suggestions on how the role of CO in cancer can be better defined. The authors also do not address the therapeutic potential of CO at all. 

The section of CO on the metabolic process does not discuss any of the studies on the role of CO donors as anti-obesity drugs. The authors need to look at the following papers PMIDs: 29295856, 30429365, 27144091, 26217498, 23689359, 23403944.

This paper has no figures. The authors should consider adding figures to emphasize the important parts of this review.

Overall, the writing of the paper needs to be significantly improved.  Here are few areas for example:

Lines 92-93, 160, 255, 258 

Author Response

Reply to Reviewer 2

     We are grateful to the Reviewer for valuable comments and thorough review of our  paper.

Please, find my replies below.

3. This is a review that attempts to describe the pharmacological properties of CO and its potential as a therapeutic agent. However, there is not much actual discussion regarding CO particularly in the section "CO in the central nervous system".
4. As suggested by the Reviewer, the section entitled "CO in the central nervous system" has been thoroughly revised in order to broaden the information on the role of CO in the central nervous system.
5. The section of CO in cancer cells is just a summary of a few different papers without any real suggestions on how the role of CO in cancer can be better defined. The authors also do not address the therapeutic potential of CO at all.

 As suggested by the Reviewer the section regarding the role of CO in cancer has been improved and better defined.

 The section of CO on the metabolic process does not discuss any of the studies on the role of CO donors as anti-obesity drugs. The authors need to look at the following papers PMIDs: 29295856, 30429365, 27144091, 26217498, 23689359, 23403944.

 As suggested by the Reviewer, the section on the role of CO in metabolic processes has been thoroughly revised and expanded to include information on the role of CO donors as anti-obesity drugs. All references indicated by the Reviewer were cited and discussed.

 This paper has no figures. The authors should consider adding figures to emphasize the important parts of this review.

By agreeing with the Reviewer's comment, we added figures to our article.

 Overall, the writing of the paper needs to be significantly improved. Here are few areas for example:

The entire paper has been thoroughly re-edited. Moreover, for significant improvement our manuscript was checked for proper English usage by a professional Polish-English translator.

We hope that the revised version of our paper now fulfils the expectations of the Reviewer.

 

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

None