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Hypoxia Increases Nitric Oxide-Dependent Inhibition of Angiogenic Growth

Int. J. Transl. Med. 2021, 1(3), 366-380; https://doi.org/10.3390/ijtm1030022

by Cristina Arce¹, Diana Vicente¹, Fermí Monto¹, Laura González¹, Cristina Nuñez¹, Víctor M. Victor^2,3

, Francesc Jiménez-Altayó⁴

and Pilar D’Ocon^1,5,*

Reviewer 1: Anonymous

Reviewer 2: Anonymous

Int. J. Transl. Med. 2021, 1(3), 366-380; https://doi.org/10.3390/ijtm1030022

Submission received: 12 November 2021 / Revised: 29 November 2021 / Accepted: 5 December 2021 / Published: 8 December 2021

(This article belongs to the Special Issue Advances in the Angiogenic Field)

Round 1

Reviewer 1 Report

See the attached file.

Comments for author File: Comments.pdf

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Could you provide better quality images for Figure 1A, 2A, 5A? It is hard to see the sprouts from the images.
Figure 3A. what is the mRNA expression level in Y-axis? is it relative to Gapdh or the absolute expression?
The quality of Figure 5C could be improved.

Author Response

Thanks for your valuable comments. We have carried out the changes recommended:

1 . Could you provide better quality images for Figure 1A, 2A, 5A? It is hard to see the sprouts from the images.

All figures has been improved in the revised version

2. Figure 3A. what is the mRNA expression level in Y-axis? is it relative to Gapdh or the absolute expression?

RNA levels are expressed relative to Gapdh as 2^-deltaCt, as it has been described in the Methods section and in the Figure legend

3. The quality of Figure 5C could be improved.

All figures has been improved in the revised version