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Volume 88
Issue 4
10.5603/ARM.a2020.0103
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Review

New Horizons from Novel Therapies in Malignant Pleural Mesothelioma

by
Mutlay Sayan
1,*,
Swati Mamidanna
1,
Mehmet Fuat Eren
2,
Vasudev Daliparty
3,
Teuta Zoto Mustafayev
4,
Carl Nelson
5,
Nisha Ohri
1,
Salma K. Jabbour
1,
Aslihan Guven Mert
4 and
Banu Atalar
4
1
Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA
2
Radiation Oncology Clinic, Marmara University Istanbul Pendik Education and Research Hospital, Istanbul, Turkey
3
Department of Internal Medicine, Raritan Bay Medical Center, Perth Amboy, NJ, USA
4
Department of Medical Oncology, Mehmet Ali Aydınlar Acıbadem University, School of Medicine, Istanbul, Turkey
5
Department of Radiation Oncology, University of Vermont Medical Center, Burlington, VT, USA
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2020, 88(4), 343-351; https://doi.org/10.5603/ARM.a2020.0103
Submission received: 19 April 2020 / Revised: 12 May 2020 / Accepted: 12 May 2020 / Published: 15 July 2020

Abstract

Malignant pleural mesothelioma (MPM) is a relatively rare, but highly lethal cancer of the pleural mesothelial cells. Its pathoge-nesis is integrally linked to asbestos exposure. In spite of recent developments providing a more detailed understanding of the pathogenesis, the outcomes continue to be poor. To date, trimodality therapy involving surgery coupled with chemotherapy and/or radiotherapy remains the standard of therapy. The development of resistance of the tumor cells to radiation and several che-motherapeutic agents poses even greater challenges in the management of this cancer. Ionizing radiation damages cancer cell DNA and aids in therapeutic response, but it also activates cell survival signaling pathways that helps the tumor cells to overcome radiation-induced cytotoxicity. A careful evaluation of the biology involved in mesothelioma with an emphasis on the workings of pro-survival signaling pathways might offer some guidance for treatment options. This review focuses on the existing treatment options for MPM, novel treatment approaches based on recent studies combining the use of inhibitors which target different pro-survival pathways, and radiotherapy to optimize treatment.
Keywords: mesothelioma; chemotherapy; radiotherapy; targeted therapy; immunotherapy mesothelioma; chemotherapy; radiotherapy; targeted therapy; immunotherapy

Share and Cite

MDPI and ACS Style

Sayan, M.; Mamidanna, S.; Eren, M.F.; Daliparty, V.; Mustafayev, T.Z.; Nelson, C.; Ohri, N.; Jabbour, S.K.; Mert, A.G.; Atalar, B. New Horizons from Novel Therapies in Malignant Pleural Mesothelioma. Adv. Respir. Med. 2020, 88, 343-351. https://doi.org/10.5603/ARM.a2020.0103

AMA Style

Sayan M, Mamidanna S, Eren MF, Daliparty V, Mustafayev TZ, Nelson C, Ohri N, Jabbour SK, Mert AG, Atalar B. New Horizons from Novel Therapies in Malignant Pleural Mesothelioma. Advances in Respiratory Medicine. 2020; 88(4):343-351. https://doi.org/10.5603/ARM.a2020.0103

Chicago/Turabian Style

Sayan, Mutlay, Swati Mamidanna, Mehmet Fuat Eren, Vasudev Daliparty, Teuta Zoto Mustafayev, Carl Nelson, Nisha Ohri, Salma K. Jabbour, Aslihan Guven Mert, and Banu Atalar. 2020. "New Horizons from Novel Therapies in Malignant Pleural Mesothelioma" Advances in Respiratory Medicine 88, no. 4: 343-351. https://doi.org/10.5603/ARM.a2020.0103

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