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Case Report

Spontaneous Resolution of Nitrofurantoin-Induced Chronic Pulmonary Toxicity Presenting with Respiratory Failure

by
Elias Mir
*,
Javed A. Malik
,
Shabir A. Lone
,
Ramees Mohi-ud-din
and
Majid Khalil
SKIMS Medical College, Bemina, Bemina, Srinagar 190018, India
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2017, 85(6), 333-338; https://doi.org/10.5603/ARM.2017.0057
Submission received: 4 September 2017 / Revised: 4 October 2017 / Accepted: 4 October 2017 / Published: 13 December 2017

Abstract

Nitrofurantoin is one of the most common drugs implicated in drug-induced pulmonary toxicities, the manifestations of which range from dose-independent acute self-limiting reactions to chronic dose-dependent pathologies. The severity of these pulmonary adverse effects may range from trivial hypersensitivity reactions to extensive and irreversible lung fibrosis leading to respiratory failure and death. Symptomatic and supportive treatment in addition to discontinuation of the drug usually suffices for the management of mild reactions. Corticosteroids have been traditionally used to relieve the symptoms and hasten the resolution of pulmonary lesions in case of severe toxicities. However conclusive evidence in the form of controlled studies in favor of this routine use is lacking. We report a case of an elderly lady who presented to us in respiratory failure due to nitrofurantoin induced chronic lung disease. The patient’s symptoms and blood gas abnormalities resolved spontaneously over the course of 6 months after stopping the drug. Radiological lesions including those suggestive of apparently permanent fibrosis also resolved during this time. Corticosteroids, inhalational or systemic, were not used. Spontaneous normalization of clinico-radiological features in nitrofurantoin induced chronic lung disease presenting with respiratory failure has rarely been reported previously. The related literature is also reviewed.
Keywords: nitrofurantoin; pulmonary; lung; drug-induced ILD; respiratory failure; corticosteroids nitrofurantoin; pulmonary; lung; drug-induced ILD; respiratory failure; corticosteroids

Share and Cite

MDPI and ACS Style

Mir, E.; Malik, J.A.; Lone, S.A.; Mohi-ud-din, R.; Khalil, M. Spontaneous Resolution of Nitrofurantoin-Induced Chronic Pulmonary Toxicity Presenting with Respiratory Failure. Adv. Respir. Med. 2017, 85, 333-338. https://doi.org/10.5603/ARM.2017.0057

AMA Style

Mir E, Malik JA, Lone SA, Mohi-ud-din R, Khalil M. Spontaneous Resolution of Nitrofurantoin-Induced Chronic Pulmonary Toxicity Presenting with Respiratory Failure. Advances in Respiratory Medicine. 2017; 85(6):333-338. https://doi.org/10.5603/ARM.2017.0057

Chicago/Turabian Style

Mir, Elias, Javed A. Malik, Shabir A. Lone, Ramees Mohi-ud-din, and Majid Khalil. 2017. "Spontaneous Resolution of Nitrofurantoin-Induced Chronic Pulmonary Toxicity Presenting with Respiratory Failure" Advances in Respiratory Medicine 85, no. 6: 333-338. https://doi.org/10.5603/ARM.2017.0057

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