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Volume 84
Issue 5
10.5603/PiAP.2016.0037
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Review

The Role of the TGF-SMAD Signalling Pathway in the Etiopathogenesis of Severe Asthma

by
Marcelina Koćwin
*,
Mateusz Jonakowski
,
Marcelina Przemęcka
,
Jan Zioło
,
Michał Panek
and
Piotr Kuna
Department of Internal Medicine, Asthma and Allergy of the Medical University of Lodz, N. Barlicki University Hospital No. 1 of Medical University of Lodz, ul. 22 Kopcinskiego, 90-153 Łódź, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2016, 84(5), 290-301; https://doi.org/10.5603/PiAP.2016.0037
Submission received: 10 April 2016 / Revised: 27 September 2016 / Accepted: 27 September 2016 / Published: 27 September 2016

Abstract

Asthma is a chronic inflammatory heterogeneous disease of the lower respiratory tract characterised by the occurrence of bronchial hyper-responsiveness and paroxysmal, changeable bronchial obstruction. Transforming growth factor-beta (TGF-β) is one of the cytokines involved in mediating airway inflammation and remodelling. The level of TGF-β1 gene expression correlates with severity of symptoms. Alterations in the main SMAD signal transmission, overexpression of TGF-β genes and changes in the transcriptome cause excessive secretion of TGF-β and its increased expression in target cells, which clinically induces a moderate-severe or severe course of asthma as well as an earlier and faster disease progression. Knowledge of these processes allows clinicians to assess immune responses in patients, which affects adequate disease control and prevention of remodelling.
Keywords: transforming growth factor β TGF-β; signalling proteins SMAD; remodelling; severe asthma transforming growth factor β TGF-β; signalling proteins SMAD; remodelling; severe asthma

Share and Cite

MDPI and ACS Style

Koćwin, M.; Jonakowski, M.; Przemęcka, M.; Zioło, J.; Panek, M.; Kuna, P. The Role of the TGF-SMAD Signalling Pathway in the Etiopathogenesis of Severe Asthma. Adv. Respir. Med. 2016, 84, 290-301. https://doi.org/10.5603/PiAP.2016.0037

AMA Style

Koćwin M, Jonakowski M, Przemęcka M, Zioło J, Panek M, Kuna P. The Role of the TGF-SMAD Signalling Pathway in the Etiopathogenesis of Severe Asthma. Advances in Respiratory Medicine. 2016; 84(5):290-301. https://doi.org/10.5603/PiAP.2016.0037

Chicago/Turabian Style

Koćwin, Marcelina, Mateusz Jonakowski, Marcelina Przemęcka, Jan Zioło, Michał Panek, and Piotr Kuna. 2016. "The Role of the TGF-SMAD Signalling Pathway in the Etiopathogenesis of Severe Asthma" Advances in Respiratory Medicine 84, no. 5: 290-301. https://doi.org/10.5603/PiAP.2016.0037

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