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Volume 84
Issue 2
10.5603/PiAP.2016.0006
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Article

Low DLCO in Idiopathic Pulmonary Arterial Hypertension—Clinical Correlates and Prognostic Significance

by
Monika Szturmowicz
1,
Aneta Kacprzak
1,*,
Monika Franczuk
2,
Barbara Burakowska
3,
Marcin Kurzyna
4,
Anna Fijałkowska
5,
Agnieszka Skoczylas
6,
Stefan Wesołowski
2,
Jan Kuś
1 and
Adam Torbicki
4
1
1st Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland
2
Department of Respiratory Physiopathology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland
3
Department of Radiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland
4
Department of Cardiovascular and Pulmonary Thromboembolic Diseases CMKP, European Health Centre Otwock, Otwock, Poland
5
Department of Cardiology, National Research Institute for Mother and Child, Warsaw, Poland
6
Freelance Statistical Analyst, Warsaw, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2016, 84(2), 87-94; https://doi.org/10.5603/PiAP.2016.0006
Submission received: 31 October 2015 / Revised: 23 March 2016 / Accepted: 23 March 2016 / Published: 23 March 2016

Abstract

Introduction: Decreased diffusing capacity of the lung for carbon monoxide (DLCO) is observed in some idiopathic pulmonary arterial hypertension (IPAH) patients, but its clinical significance is uncertain. We aimed to assess clinical correlates and prognostic significance of low DLCO in IPAH patients. Material and methods: In the group of 65 IPAH patients the cut off value for low DLCO was set up based on histogram as < 55% of predicted value. Demographic data, exercise capacity, lung function tests, hemodynamic parameters and survival of the patients were compared depending on DLCO value. Results: Low DLCO was found in 18% of the patients, and it was associated with male sex, older age, worse functional status and exercise capacity, and higher prevalence of coronary artery disease. Low DLCO carried a 4-fold increase of death risk in 5-year perspective. Conclusions: Low DLCO was a marker of worse functional capacity and increased risk of death in studied IPAH patients.
Keywords: diffusing capacity for carbon monoxide; pulmonary hypertension; prognostic factor diffusing capacity for carbon monoxide; pulmonary hypertension; prognostic factor

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MDPI and ACS Style

Szturmowicz, M.; Kacprzak, A.; Franczuk, M.; Burakowska, B.; Kurzyna, M.; Fijałkowska, A.; Skoczylas, A.; Wesołowski, S.; Kuś, J.; Torbicki, A. Low DLCO in Idiopathic Pulmonary Arterial Hypertension—Clinical Correlates and Prognostic Significance. Adv. Respir. Med. 2016, 84, 87-94. https://doi.org/10.5603/PiAP.2016.0006

AMA Style

Szturmowicz M, Kacprzak A, Franczuk M, Burakowska B, Kurzyna M, Fijałkowska A, Skoczylas A, Wesołowski S, Kuś J, Torbicki A. Low DLCO in Idiopathic Pulmonary Arterial Hypertension—Clinical Correlates and Prognostic Significance. Advances in Respiratory Medicine. 2016; 84(2):87-94. https://doi.org/10.5603/PiAP.2016.0006

Chicago/Turabian Style

Szturmowicz, Monika, Aneta Kacprzak, Monika Franczuk, Barbara Burakowska, Marcin Kurzyna, Anna Fijałkowska, Agnieszka Skoczylas, Stefan Wesołowski, Jan Kuś, and Adam Torbicki. 2016. "Low DLCO in Idiopathic Pulmonary Arterial Hypertension—Clinical Correlates and Prognostic Significance" Advances in Respiratory Medicine 84, no. 2: 87-94. https://doi.org/10.5603/PiAP.2016.0006

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