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Proceeding Paper

Structural Study of Three 1,2,4-triazole Derivatives Prepared by Oxidative Cyclization of Thiosemicarbazides †

by
Mirian Artime
,
Alfonso Castiñeiras
,
Isabel García-Santos
* and
Manuel Saa
Department of Inorganic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
†
Presented at the 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2018; Available Online: https://sciforum.net/conference/ecsoc-22.
Proceedings 2019, 9(1), 20; https://doi.org/10.3390/ecsoc-22-05852
Published: 14 November 2018
(This article belongs to the Proceedings of 22nd International Electronic Conference on Synthetic Organic Chemistry)
Versions Notes

Abstract

In the present research, 5,5-dimethyl-4-phenyl-4,5-dihydro-3H-1,2,4-triazole-3-thione (1) was prepared by condensation from N-phenylhydrazinecarbothioamide, while 4-phenyl-5-(pyrazin-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (2) and 2-((5-(pyridin-2-yl) -4H-1,2,4-triazol-3-yl)thio)acetic acid (3) was prepared by oxidative cyclization from 2-(amino(pyrazin-2-yl)methylene)-N-phenylhydrazine-1-carbothioamide and 2-(amino(pyridine-2-yl)methylene)hydrazine-1-carbothioamide, respectively. The three compounds have been well characterized and their molecular structures studied by single-crystal X-ray diffraction. The supramolecular assembly of each crystal has also been analyzed and discussed.
Keywords: thiosemicarbazones; 1,2,4-triazole; oxidative cyclization; supramolecular architectures; hydrogen bond thiosemicarbazones; 1,2,4-triazole; oxidative cyclization; supramolecular architectures; hydrogen bond

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MDPI and ACS Style

Artime, M.; Castiñeiras, A.; García-Santos, I.; Saa, M. Structural Study of Three 1,2,4-triazole Derivatives Prepared by Oxidative Cyclization of Thiosemicarbazides. Proceedings 2019, 9, 20. https://doi.org/10.3390/ecsoc-22-05852

AMA Style

Artime M, Castiñeiras A, García-Santos I, Saa M. Structural Study of Three 1,2,4-triazole Derivatives Prepared by Oxidative Cyclization of Thiosemicarbazides. Proceedings. 2019; 9(1):20. https://doi.org/10.3390/ecsoc-22-05852

Chicago/Turabian Style

Artime, Mirian, Alfonso Castiñeiras, Isabel García-Santos, and Manuel Saa. 2019. "Structural Study of Three 1,2,4-triazole Derivatives Prepared by Oxidative Cyclization of Thiosemicarbazides" Proceedings 9, no. 1: 20. https://doi.org/10.3390/ecsoc-22-05852

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