Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique
Round 1
Reviewer 1 Report
This manuscript demonstrated the micronization of curcumin with PVP by usinig the electrospray technique, which will help to control the particle size. However, I found several mistakes and insufficient contents as follows. Therefore, I cannot accept this manuscript in a present form.
p.1, line 22. 15cm Moreover -> 15cm. Moreover
p.2, last paragraph. No discription about the formation mechanism of several holes in fabricated particle as shown in Fig. 3(a).
p.3, Figures 2 and 3. The scale bar is unclear.
p.8, The corresponding peaks such as O-H bending C-O-streaching should be added in FIg. 7.
Author Response
Dear Reviewer 1
Thank you very much for your good comments and suggestions concerning our manuscript entitled “Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique” (Ms. Ref. No.: ChemEngineering-383084).
We have revised the manuscript. The revised words are marked in the red one. Since the paper has been revised, we would like to re-submit this revised manuscript to “ChemEngineering”, and hope it is acceptable for publication in this journal
Thank you very much for your consideration. I look forward to hearing from you.
Sincerely,
Wahyudiono
Department of Materials Process Engineering, Nagoya University
Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Email address: wahyudiono@b.mbox.nagoya-u.ac.jp
Author Response File: 
Author Response.docx
Reviewer 2 Report
Method of obtaining curcumin/PVP particles using electrospraying process was developed. Authors established influence of operational parameters on morphology and particle size distribution. Research were well planned and their results were clearly presented. Moreover, obtained results were discussed in reference to data known from literature. What is important, mainly recent articles were cited.
Only some minor points require attention:
-p2, line 47 - “pray drying” - the “s” is missing in a word “spray”
- page 3, line 102 – please provide some information about samples preparation for FT-IR analysis. Have pellets made of sample and KBr been used?
-p3, line 106 – “The dissolution of the original curcumin, curcumin, and the curcumin/PVP particles” – did you mean “original curcumin, curcumin PARTICLES, and the curcumin/PVP particles”?
- please add scale bar to each SEM image,
- page 4, line 139 – it should be Figure 3b, instead of Figure 3a - the sentence is about PVP particles. While at line 142 it should be Figure 3a - original PVP particles are presented at Fig 3a,
- solubility of curcumin/PVP particles has been discussed in literature . Therefore, a brief comment about solubility of obtained curcumin/polyvinylpyrrolidone microparticles in comparison to data known from literature could be provided.
Author Response
Dear Reviewer 2
Thank you very much for your good comments and suggestions concerning our manuscript entitled “Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique” (Ms. Ref. No.: ChemEngineering-383084).
We have revised the manuscript. The revised words are marked in the red one. Since the paper has been revised, we would like to re-submit this revised manuscript to “ChemEngineering”, and hope it is acceptable for publication in this journal
Thank you very much for your consideration. I look forward to hearing from you.
Sincerely,
Wahyudiono
Department of Materials Process Engineering, Nagoya University
Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Email address: wahyudiono@b.mbox.nagoya-u.ac.jp
Author Response File: Author Response.docx
Reviewer 3 Report
The paper could be published in present form.
Author Response
Thank you very much for your good comments and suggestions concerning our manuscript entitled “Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique” (Ms. Ref. No.: ChemEngineering-383084).
Author Response File: 
Author Response.pdf
Reviewer 4 Report
Please, see attachment.
Comments for author File: Comments.pdf
Author Response
Dear Reviewer
Thank you very much for your good comments and suggestions concerning our manuscript entitled “Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique” (Ms. Ref. No.: ChemEngineering-383084).
We have revised the manuscript. The revised words are marked in the red one. Since the paper has been revised, we would like to re-submit this revised manuscript to “ChemEngineering”, and hope it is acceptable for publication in this journal
Thank you very much for your consideration. I look forward to hearing from you.
Sincerely,
Wahyudiono
Department of Materials Process Engineering, Nagoya University
Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Email address: wahyudiono@b.mbox.nagoya-u.ac.jp
Author Response File: Author Response.pdf
