Carcinogenic Activity and Risk Assessment of PAHs in Ambient Air: PM10 Particle Fraction and Bulk Deposition
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sampling
2.2. Analysis of PAHs in PM10 Particle Fraction
2.3. Analysis of PAHs in Bulk Deposition Samples
2.4. Statistical Analysis
2.5. Cancer Risk Assessment of PAHs
2.6. Ecological Risk Assessment of PAHs
3. Results and Discussion
3.1. Carcinogenic Activity of PAHs in Atmospheric Particulate Matter and Bulk Deposition
3.2. Risk Assessment of PAHs
3.2.1. Human Health Risk Assessment
3.2.2. Ecological Risk Assessment
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable Definition | Symbol | Units | Children | Adults |
---|---|---|---|---|
Body weight | BW | kg | 20 | 80 |
Exposure frequency | EF | day year−1 | 350 | 350 |
Exposure duration | ED | year | 6 | 40 |
Ingestion rate | IRs | mg day−1 | 200 | 100 |
Dermal exposure area | SA | cm2 | 3107 | 4615 |
Dermal adherence factor | AF | mg cm−2 | 0.20 | 0.07 |
Dermal absorption factor | ABS | unitless | 0.13 | 0.13 |
Averaging life span | AT | day | 25550 | 25550 |
Inhalation rate | IRα | m3 h−1 | 1.3 | 3.3 |
Exposure time | ET | h day−1 | 8 | 8 |
Particle emission factor | PEF | m3 kg−1 | 1.36 × 109 | 1.36 × 109 |
Ingestion carcinogenic slope factor | CSFing | (mg kg−1 day−1)−1 | 7.3 | 7.3 |
Dermal carcinogenic slope factor | CSFderm | (mg kg−1 day−1)−1 | 25 | 25 |
Inhalation carcinogenic slope factor | CSFinh | (mg kg−1 day−1)−1 | 3.14 | 3.14 |
Children | Adults | ||||
---|---|---|---|---|---|
Central | Worst | Central | Worst | ||
Cold period | Ding | 67.110 | 196.592 | 55.925 | 163.827 |
Dder | 27.107 | 79.405 | 23.487 | 68.801 | |
Dinh | 0.003 | 0.008 | 0.011 | 0.032 | |
Warm period | Ding | 6.798 | 86.528 | 5.665 | 72.106 |
Dder | 2.746 | 34.949 | 2.379 | 30.282 | |
Dinh | 0.0003 | 0.003 | 0.001 | 0.014 |
Children | Adults | ||||
---|---|---|---|---|---|
Central | Worst | Central | Worst | ||
Cold period | Risking | 4.90 × 10−4 | 1.44 × 10−3 | 4.08 × 10−4 | 1.20 × 10−3 |
Riskder | 6.78 × 10−4 | 1.99 × 10−3 | 5.87 × 10−4 | 1.72 × 10−3 | |
Riskinh | 8.06 × 10−9 | 2.36 × 10−8 | 3.41 × 10−8 | 9.99 × 10−8 | |
Risktot | 1.17 × 10−3 | 3.42 × 10−3 | 9.95 × 10−4 | 2.92 × 10−3 | |
Warm period | Risking | 4.96 × 10−5 | 6.32 × 10−4 | 4.14 × 10−5 | 5.26 × 10−4 |
Riskder | 6.86 × 10−5 | 8.74 × 10−4 | 5.95 × 10−5 | 7.57 × 10−4 | |
Riskinh | 8.16 × 10−4 | 1.04 × 10−8 | 3.45 × 10−9 | 4.40 × 10−8 | |
Risktot | 1.18 × 10−4 | 1.51 × 10−3 | 1.01 × 10−4 | 1.28 × 10−3 |
Individual PAHs | ∑PAHs | ||||
---|---|---|---|---|---|
RQNCs | RQMPCs | RQ∑PAHs(NCs) | RQ∑PAHs(MPCs) | ||
Risk-free | 0 | Risk-free | 0 | ||
Low-risk | ≥1; <800 | 0 | |||
Moderate-risk | ≥1 | <1 | Moderate-risk1 | ≥800 | 0 |
Moderate-risk2 | <800 | ≥1 | |||
High-risk | ≥1 | High-risk | ≥800 | ≥1 |
PAHs | RQ(NCs) | RQ(MPCs) |
---|---|---|
Flu | 0.0 | 0.0 |
Pyr | 0.1 | 0.0 |
BaA | 13.5 | 0.1 |
Chry | 0.1 | 0.0 |
BbF | 21.8 | 0.2 |
BkF | 2.2 | 0.0 |
BaP | 14.4 | 0.1 |
DahA | 0.3 | 0.0 |
BghiP | 0.4 | 0.0 |
IP | 3.4 | 0.0 |
∑PAHs | 55.3 | - |
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Jakovljević, I.; Smoljo, I.; Sever Štrukil, Z.; Pehnec, G. Carcinogenic Activity and Risk Assessment of PAHs in Ambient Air: PM10 Particle Fraction and Bulk Deposition. Toxics 2023, 11, 228. https://doi.org/10.3390/toxics11030228
Jakovljević I, Smoljo I, Sever Štrukil Z, Pehnec G. Carcinogenic Activity and Risk Assessment of PAHs in Ambient Air: PM10 Particle Fraction and Bulk Deposition. Toxics. 2023; 11(3):228. https://doi.org/10.3390/toxics11030228
Chicago/Turabian StyleJakovljević, Ivana, Iva Smoljo, Zdravka Sever Štrukil, and Gordana Pehnec. 2023. "Carcinogenic Activity and Risk Assessment of PAHs in Ambient Air: PM10 Particle Fraction and Bulk Deposition" Toxics 11, no. 3: 228. https://doi.org/10.3390/toxics11030228