3′-Aminothiocyclohexanespiro-5′-hydantoin and Its Pt(II) Complex—Synthesis, Cytotoxicity and Xanthine Oxidase Inhibitory Activity
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis
2.2. Spectral Characterization and Geometry Optimization
2.2.1. Spectral Analysis
2.2.2. Quantum Chemical Modeling
2.3. Biological Evaluation
2.3.1. Antiproliferative Activity
2.3.2. XO Activity
3. Molecular Docking Study
4. Materials and Methods
4.1. Synthesis
Cis-Amminedichlorido-(3′-aminothiocyclohexanespiro-5′-hydantoin) Platinum (II)—Cis-[PtL(NH3)Cl2], Complex 2
4.2. Quantum Chemical Modeling
4.3. Biological Evaluation
4.4. Evaluation of XO Inhibition
4.5. Molecular Docking to Xanthine Oxidase
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Compound | Affinity dG |
---|---|
Ligand 1 | −3.9795 |
Complex 2 | −6.5197 |
Ligand 3 | −3.4150 |
Complex 4 | −6.7772 |
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Cherneva, E.; Atanasova, M.; Šmelcerović, Ž.; Tomović, K.; Buyukliev, R.; Šmelcerović, A.; Bakalova, A. 3′-Aminothiocyclohexanespiro-5′-hydantoin and Its Pt(II) Complex—Synthesis, Cytotoxicity and Xanthine Oxidase Inhibitory Activity. Inorganics 2022, 10, 175. https://doi.org/10.3390/inorganics10100175
Cherneva E, Atanasova M, Šmelcerović Ž, Tomović K, Buyukliev R, Šmelcerović A, Bakalova A. 3′-Aminothiocyclohexanespiro-5′-hydantoin and Its Pt(II) Complex—Synthesis, Cytotoxicity and Xanthine Oxidase Inhibitory Activity. Inorganics. 2022; 10(10):175. https://doi.org/10.3390/inorganics10100175
Chicago/Turabian StyleCherneva, Emiliya, Mariyana Atanasova, Žaklina Šmelcerović, Katarina Tomović, Rossen Buyukliev, Andrija Šmelcerović, and Adriana Bakalova. 2022. "3′-Aminothiocyclohexanespiro-5′-hydantoin and Its Pt(II) Complex—Synthesis, Cytotoxicity and Xanthine Oxidase Inhibitory Activity" Inorganics 10, no. 10: 175. https://doi.org/10.3390/inorganics10100175