Competing Endogenous RNAs in Cervical Carcinogenesis: A New Layer of Complexity
, Sara Cristina Lobo-Alves 2, Camila de Freitas Oliveira-Toré 3, Amanda Salviano-Silva 1, Karen Brajão de Oliveira 4, PatrÃcia Savio de Araújo-Souza 1, Jong Kook Park 5, Gabriel Adelman Cipolla 1,†and Danielle Malheiros 1,*,†Round 1
Reviewer 1 Report
A very important review showing the latest data. It may be of use to many researchers studying the role of non-coding RNAs in carcinogenesis
Author Response
Please find attached the response to your comment.
Sincerly,
Danielle Malheiros
Author Response File: 
Author Response.pdf
Reviewer 2 Report
This paper provided a detailed review of interactions between long noncoding RNAs (lncRNA) and microRNAs (miRNA) involved in cervical cancer. miRNAs may interact in competing endogenous RNAs (ceRNAs) axes to regulate mRNA. The topic focuses on the discussion of lncRNA-mediated ceRNA networks. This paper is an interesting contribution to this field.
I only have a minor comment. In Table 3, all of the population discussed in this paper are Chinese except for one Russian population. Why did you only focus on Chinese samples? In this case, should you remove the Russian population and retitle to focus on the Chinese population?
Author Response
Please find attached the response to your comments.
Sincerly,
Danielle Malheiros
Author Response File: Author Response.pdf
Reviewer 3 Report
processes-1238885
Competing Endogenous RNAs in Cervical Carcinogenesis: a new layer of complexity
Fernanda Costa Brandão Berti et al.
In this review article, the authors describe networks involved in cervical cancer, highlighting major impacts of such dynamic molecular changes over multiple cellular processes. Through sponging distinct miRNAs, some lncRNAs trigger crucial molecular changes, ultimately increasing cell proliferation, migration, invasion, and inhibiting apoptosis. They highlight important lncRNA-mediated functional interactions occurring in cervical cells, and their closely related impact on cervical carcinogenesis.
This review is well written and describe lncRNA and miRNA axis for cancer cells in CC.
I have suggestions for this manuscript as follows.
1) As HOTAIR, MALAT1, NEAT1 and XIST are all nuclear lncRNAs, it would be better to have discussion of the interaction between lncRNAs and miRNAs from the localization point of view.
2) It would be more helpful if the authors could include information for molecular numbers of each miRNA and lncRNA in CC to get information about their abundance and molecular ratio.
Author Response
Please find attached the response to your comments.
Sincerly,
Danielle Malheiros
Author Response File: Author Response.pdf
