Dynamic DNA Methylation Changes in the COMT Gene Promoter Region in Response to Mental Stress and Its Modulation by Transcranial Direct Current Stimulation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Adaptive 2-Back Paced Auditory Serial Addition Task (PASAT)
2.3. Positive and Negative Affect Schedule (PANAS)
2.4. Transcranial Direct Current Stimulation (tDCS)
2.5. Experimental Procedure
2.6. DNAm Analysis
2.7. Saliva Cortisol Concentration
2.8. Statistical Analysis
3. Results
3.1. Study Sample
3.2. Task Performance
3.3. Affective Changes
3.4. DNAm Changes in COMT Gene Promoter Region
3.5. Cortisol Changes
3.6. Correlation of DNAm Changes and Cortisol Changes
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wiegand, A.; Blickle, A.; Brückmann, C.; Weller, S.; Nieratschker, V.; Plewnia, C. Dynamic DNA Methylation Changes in the COMT Gene Promoter Region in Response to Mental Stress and Its Modulation by Transcranial Direct Current Stimulation. Biomolecules 2021, 11, 1726. https://doi.org/10.3390/biom11111726
Wiegand A, Blickle A, Brückmann C, Weller S, Nieratschker V, Plewnia C. Dynamic DNA Methylation Changes in the COMT Gene Promoter Region in Response to Mental Stress and Its Modulation by Transcranial Direct Current Stimulation. Biomolecules. 2021; 11(11):1726. https://doi.org/10.3390/biom11111726
Chicago/Turabian StyleWiegand, Ariane, Arne Blickle, Christof Brückmann, Simone Weller, Vanessa Nieratschker, and Christian Plewnia. 2021. "Dynamic DNA Methylation Changes in the COMT Gene Promoter Region in Response to Mental Stress and Its Modulation by Transcranial Direct Current Stimulation" Biomolecules 11, no. 11: 1726. https://doi.org/10.3390/biom11111726