Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency
Abstract
:1. Introduction
2. Materials and Methods
2.1. Model Development
2.2. Parameters
2.3. Bifurcation Analysis
2.4. Stochastic Model
3. Results
3.1. Exploring Model Behaviour
3.2. Experimentally Testable Predictions
3.2.1. Inhibition of Transcription via a Notch Signalling Inhibitor
3.2.2. Treatment with a Translational Inhibitor
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Parameter | Description | Value | Units |
---|---|---|---|
Maximal transcription rate | 3.03 | min | |
mRNA degradation rate | 0.03 | min | |
Background translation rate | 0.12 | min | |
X dependent translation rate | 20.12 | min | |
P degradation rate | 0.30 | min | |
Max. X | 70.43 | Nondim | |
Translation IC50 | 1 | Nondim | |
Transcription IC50 | 40 | Nondim | |
Protein noise strength | 1.0 | min | |
mRNA noise strength | 0.12 | min | |
mRNA initial condition | 6 | Nondim | |
protein initial condition | 60 | Nondim |
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Murray, P.J.; Ocana, E.; Meijer, H.A.; Dale, J.K. Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency. Biomolecules 2021, 11, 1566. https://doi.org/10.3390/biom11111566
Murray PJ, Ocana E, Meijer HA, Dale JK. Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency. Biomolecules. 2021; 11(11):1566. https://doi.org/10.3390/biom11111566
Chicago/Turabian StyleMurray, Philip J., Eleonore Ocana, Hedda A. Meijer, and Jacqueline Kim Dale. 2021. "Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency" Biomolecules 11, no. 11: 1566. https://doi.org/10.3390/biom11111566