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Sci. Pharm.
Volume 77
Issue 3
10.3797/scipharm.0812-10
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Antipyretic Potential of Swertia chirata Buch Ham. Root Extract

by
Sushil BHARGAVA
1,*,
Prakash S. RAO
1,
Paridhi BHARGAVA
2 and
Shivshankar SHUKLA
2
1
Columbia Institute of Pharmacy, Tekari, Raipur, 493111, Chhattisgarh, India
2
Institute of Pharmacy, Pt. Ravishankar Sukla University, Raipur, 493111, Chhattisgarh, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(3), 617-624; https://doi.org/10.3797/scipharm.0812-10
Submission received: 18 December 2008 / Accepted: 1 July 2009 / Published: 4 July 2009
Versions Notes

Abstract

The aqueous extract of Swertia chirata Buch Ham. Root (ASC) (Family: Gentianaceae) was evaluated for its antipyretic potential on Brewer’s yeastinduced pyrexia in albino rats and Typhoid-Paratyphoid A, B vaccine induced Hyperexia in rabbits. In both models, the extract, at dose of 200 mg kg−1 body wt. and 400 mg kg−1 body weight, produced significant (p<0.001) reduction in elevated body temperature in a dose dependent manner. The antipyretic effect of the extract was comparable to that of paracetamol (150 mg kg−1 body weight, p.o.), a standard antipyretic agent.
Keywords: Swertia chirata; Chirayta; Antipyretic; Hyperexia; Fever Swertia chirata; Chirayta; Antipyretic; Hyperexia; Fever

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MDPI and ACS Style

BHARGAVA, S.; RAO, P.S.; BHARGAVA, P.; SHUKLA, S. Antipyretic Potential of Swertia chirata Buch Ham. Root Extract. Sci. Pharm. 2009, 77, 617-624. https://doi.org/10.3797/scipharm.0812-10

AMA Style

BHARGAVA S, RAO PS, BHARGAVA P, SHUKLA S. Antipyretic Potential of Swertia chirata Buch Ham. Root Extract. Scientia Pharmaceutica. 2009; 77(3):617-624. https://doi.org/10.3797/scipharm.0812-10

Chicago/Turabian Style

BHARGAVA, Sushil, Prakash S. RAO, Paridhi BHARGAVA, and Shivshankar SHUKLA. 2009. "Antipyretic Potential of Swertia chirata Buch Ham. Root Extract" Scientia Pharmaceutica 77, no. 3: 617-624. https://doi.org/10.3797/scipharm.0812-10

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